Detailed view for PVX_114990

Basic information

TDR Targets ID: 265505
Plasmodium vivax, guanylyl cyclase, putative
Source Database / ID:  PlasmoDB 

pI: 9.6735 | Length (AA): 3144 | MW (Da): 364219 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 21

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain
PF16212   Phospholipid-translocating P-type ATPase C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016849   phosphorus-oxygen lyase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
831 1054 1ymq (A) 24 257 10.00 0.0000000031 0.02 0.1 -0.27
1619 1871 1fx4 (A) 876 1099 17.00 0 0.66 0.17 -0.26
1626 1863 1azs (B) 880 1075 30.00 0 1 -0.1 0.31
2944 3106 1wc3 (A) 1006 1174 24.00 0 1 0.46 -1.2
44 285 4bj6 (A) 79 387 26.00 0.69 0.76 0.171772 0.31
584 766 2aqw (A) 17 196 28.00 0.23 0.69 0.197006 0.4
1596 1839 1fx4 (A) 877 1091 21.00 0 0.83 0.142108 0.3
1597 1840 4p2f (A) 240 422 38.00 0 1 0.135408 0.72
1601 1839 3et6 (A) 470 650 35.00 0 1 -0.00448219 1.22
1607 1839 1wc3 (A) 1011 1195 24.00 0 1 0.0866094 0.29
1732 1839 1azs (B) 968 1075 37.00 0.0000000000056 0.93 0.482151 0.05
2033 2151 2vsy (A) 32 138 7.00 0.099 0 -0.0117501 -0.22
2083 2159 3k9i (A) 54 129 8.00 0.19 0.01 0.175891 -1.12
2922 3122 2w01 (A) 439 634 21.00 0 0.58 0.299431 -0.32
2923 3080 3r5g (A) 226 384 25.00 0.00028 0.86 0.452054 -0.76
2925 3082 1wc3 (A) 1011 1174 25.00 0.018 0.96 0.329054 -0.43
2925 3071 2w01 (A) 442 586 30.00 0.0088 0.71 0.356556 0.11
2970 3113 3r5g (A) 273 414 21.00 0.00066 0.88 0.237202 0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_156251)

Species Accession Gene Product
Plasmodium berghei PBANKA_1136700   guanylyl cyclase beta
Plasmodium falciparum PF3D7_1360500   guanylyl cyclase beta
Plasmodium knowlesi PKNH_1110800   guanylyl cyclase, putative
Plasmodium vivax PVX_114990   guanylyl cyclase, putative
Plasmodium yoelii PY00952   guanylyl cyclase enzyme-related
Plasmodium yoelii PY00951   guanylyl cyclase enzyme-related
Plasmodium yoelii PY02999   guanylyl cyclase enzyme-related

Essentiality

PVX_114990 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1136700 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_114990 (Plasmodium vivax), guanylyl cyclase, putative
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