pI: 7.3748 |
Length (AA): 340 |
MW (Da): 40057 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 322 | 2ble (A) | 17 | 342 | 11.00 | 0 | 1 | 0.69 | 0.3 |
27 | 322 | 1vhn (A) | 6 | 307 | 18.00 | 0 | 1 | 1.06 | -1.25 |
27 | 327 | 1vhn (A) | 6 | 299 | 19.00 | 0 | 1 | 1.17 | -0.8 |
26 | 248 | 3b0p (A) | 4 | 233 | 25.00 | 0.0000000077 | 1 | 0.972082 | -0.63 |
26 | 338 | 4xp7 (A) | 12 | 332 | 24.00 | 0.00000087 | 1 | 1.14689 | -0.31 |
27 | 277 | 4xp7 (A) | 13 | 283 | 32.00 | 0 | 1 | 1.02444 | -0.33 |
27 | 335 | 1vhn (A) | 6 | 307 | 20.00 | 0.000000000011 | 1 | 1.17392 | -0.45 |
109 | 247 | 3w9z (A) | 92 | 231 | 35.00 | 0.0000000045 | 0.99 | 0.772024 | -0.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 12 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 36 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 30 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_127749)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G67220 | FMN-linked oxidoreductases superfamily protein |
Babesia bovis | BBOV_IV004780 | dihydrouridine synthase, putative |
Brugia malayi | Bm1_48360 | PP3111 protein |
Candida albicans | CaO19.1404 | likely tRNA dihydrouridine synthase similar to S. cerevisiae DUS1 (YML080W) dihydrouridine synthase specific for pre-tRNA-Phe |
Candida albicans | CaO19.8982 | likely tRNA dihydrouridine synthase similar to S. cerevisiae DUS1 (YML080W) dihydrouridine synthase specific for pre-tRNA-Phe |
Caenorhabditis elegans | CELE_F36A2.2 | Protein F36A2.2 |
Cryptosporidium hominis | Chro.10384 | ENSANGP00000019228 |
Cryptosporidium parvum | cgd1_3440 | Dus1p, tRNA dihydrouridine synthase |
Dictyostelium discoideum | DDB_G0278803 | tRNA-dihydrouridine synthase 1-like protein |
Drosophila melanogaster | Dmel_CG3645 | CG3645 gene product from transcript CG3645-RA |
Echinococcus granulosus | EgrG_000616200 | tRNA dihydrouridine synthase 1 |
Entamoeba histolytica | EHI_164780 | dihydrouridine synthase (Dus) family protein |
Echinococcus multilocularis | EmuJ_000616200 | tRNA dihydrouridine synthase 1 |
Giardia lamblia | GL50803_5213 | tRNA dihydrouridine synthase, putative |
Homo sapiens | 64118 | dihydrouridine synthase 1-like (S. cerevisiae) |
Leishmania braziliensis | LbrM.31.2160 | dihydrouridine synthase (Dus), putative |
Leishmania donovani | LdBPK_311970.1 | dihydrouridine synthase (Dus), putative |
Leishmania infantum | LinJ.31.1970 | dihydrouridine synthase (Dus), putative |
Leishmania major | LmjF.31.1930 | dihydrouridine synthase (Dus), putative |
Leishmania mexicana | LmxM.30.1930 | dihydrouridine synthase (Dus), putative |
Loa Loa (eye worm) | LOAG_05027 | hypothetical protein |
Mus musculus | ENSMUSG00000025155 | dihydrouridine synthase 1-like (S. cerevisiae) |
Neospora caninum | NCLIV_022120 | dihydrouridine synthase domain-containing protein, putative |
Oryza sativa | 4342049 | Os06g0712900 |
Plasmodium berghei | PBANKA_1033600 | tRNA-dihydrouridine synthase, putative |
Plasmodium falciparum | PF3D7_1408900 | tRNA-dihydrouridine synthase, putative |
Plasmodium knowlesi | PKNH_1349500 | tRNA-dihydrouridine synthase, putative |
Plasmodium vivax | PVX_086005 | tRNA-dihydrouridine synthase, putative |
Plasmodium yoelii | PY01376 | Drosophila melanogaster CG3645 gene product |
Saccharomyces cerevisiae | YML080W | Dus1p |
Schistosoma japonicum | Sjp_0200030 | ko:K05542 tRNA-dihydrouridine synthase 1, putative |
Schistosoma mansoni | Smp_096200 | tRNA-dihydrouridine synthase |
Schmidtea mediterranea | mk4.002092.03 | |
Trypanosoma brucei gambiense | Tbg972.8.7840 | tRNA-dihydrouridine synthase 1, putative |
Trypanosoma brucei | Tb927.8.7570 | tRNA-dihydrouridine synthase 1, putative |
Trypanosoma congolense | TcIL3000_8_7960 | tRNA-dihydrouridine synthase 1, putative |
Trypanosoma congolense | TcIL3000_8_7820 | dihydrouridine synthase (Dus), putative |
Trypanosoma congolense | TcIL3000_0_23020 | tRNA-dihydrouridine synthase 1, putative |
Trypanosoma cruzi | TcCLB.504173.50 | dihydrouridine synthase (Dus), putative |
Trypanosoma cruzi | TcCLB.506107.20 | dihydrouridine synthase (Dus), putative |
Toxoplasma gondii | TGME49_202790 | dihydrouridine synthase (dus) protein |
Theileria parva | TP01_0269 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_353310 | tRNA-dihydrouridine synthase, putative |
Trichomonas vaginalis | TVAG_021320 | tRNA-dihydrouridine synthase, putative |
Trichomonas vaginalis | TVAG_251740 | tRNA-dihydrouridine synthase, putative |
Trichomonas vaginalis | TVAG_323330 | tRNA-dihydrouridine synthase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.7570 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.7570 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.7570 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.7570 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1033600 | Plasmodium berghei | Dispensable | plasmo |
TGME49_202790 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.