Detailed view for PVX_117175

Basic information

TDR Targets ID: 265763
Plasmodium vivax, dynein beta chain, putative
Source Database / ID:  PlasmoDB 

pI: 6.6293 | Length (AA): 6398 | MW (Da): 742238 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03028   Dynein heavy chain and region D6 of dynein motor
PF08385   Dynein heavy chain, N-terminal region 1
PF08393   Dynein heavy chain, N-terminal region 2
PF12774   Hydrolytic ATP binding site of dynein motor region D1
PF12775   P-loop containing dynein motor region D3
PF12777   Microtubule-binding stalk of dynein motor
PF12781   ATP-binding dynein motor region D5

Gene Ontology

Mouse over links to read term descriptions.
GO:0030286   dynein complex  
GO:0005622   intracellular  
GO:0005524   ATP binding  
GO:0004198   calcium-dependent cysteine-type endopeptidase activity  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
30 918 2x1g (F) 20 962 10.00 0 1 0.00374967 0.36
135 1167 4hzk (A) 67 1058 11.00 0 1 0.0162567 0.71
769 1210 4a3t (A) 8 464 14.00 0 0.6 -0.141116 0.74
1423 6394 3vkg (A) 1411 4725 21.00 0 1 -0.133082 2.44
2507 2543 3bog (C) 3 79 46.00 0.9 0.1 0.738783 -2.75
4624 4763 2rr7 (A) 2 155 39.00 0.000000000034 1 0.493882 -0.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_144716)

Species Accession Gene Product
Plasmodium berghei PBANKA_1329200   dynein beta chain, putative
Plasmodium falciparum PF3D7_1465800   dynein beta chain, putative
Plasmodium knowlesi PKNH_1215700   dynein beta chain, putative
Plasmodium vivax PVX_117175   dynein beta chain, putative
Plasmodium yoelii PY02001   hypothetical protein
Plasmodium yoelii PY02003   hypothetical protein
Plasmodium yoelii PY02002   1 beta dynein heavy chain
Plasmodium yoelii PY04739   1 beta dynein heavy chain
Schistosoma mansoni Smp_098490   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_117175 (Plasmodium vivax), dynein beta chain, putative
Title for this comment
Comment