Detailed view for LmjF.35.4000

Basic information

TDR Targets ID: 26612
Leishmania major, protein kinase, putative,MAP kinase kinase-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.2447 | Length (AA): 1343 | MW (Da): 147262 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00632   HECT-domain (ubiquitin-transferase)
PF07719   Tetratricopeptide repeat
PF13181   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0016881   acid-amino acid ligase activity  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  
GO:0006464   protein modification process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 19 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
44 185 1a17 () 28 173 26.00 0 1 0.46 -0.75
44 126 1w3b (A) 317 399 19.00 0.00000066 0.53 0.44 -1.61
466 932 1qcf (A) 87 531 16.00 0 1 0.4 0.47
644 923 1phk () 16 290 24.00 0 1 0.52 -1.13
647 985 1kob (A) 53 373 22.00 0 1 0.53 -0.69
938 1336 1nd7 (A) 544 916 21.00 0 1 0.49 -0.44
37 164 3sz7 (A) 107 234 29.00 0 1 0.570409 -1.11
41 163 3upv (A) 259 381 25.00 0 1 0.492086 -1.22
44 231 4ja7 (A) 28 209 24.00 0 1 0.326085 0.38
48 122 4cgu (A) 8 88 36.00 0.017 0.82 0.320645 -0.1
429 784 4o1p (A) 146 501 21.00 0.00000000063 0.81 0.280178 1.3
496 962 3pvu (A) 40 519 19.00 0 1 0.453829 0.48
641 910 3g2f (A) 197 493 30.00 0 1 0.350142 0.05
643 1031 2rio (A) 12 421 22.00 0 1 0.34075 0.73
685 940 4fgb (A) 53 297 27.00 0.0000000021 1 0.469418 -0.46
748 853 4wnk (A) 294 378 41.00 0.021 0.88 0.250728 0.29
921 1335 3olm (A) 415 802 19.00 0 1 0.36211 0.51
963 1336 1c4z (A) 502 846 28.00 0 1 0.429281 0.72
1247 1333 3pt3 (A) 2702 2791 23.00 0 0.58 0.27728 -1.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_163570)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0276527   CAMKL family protein kinase
Leishmania braziliensis LbrM.34.3980   protein kinase, putative,MAP kinase kinase-like protein
Leishmania donovani LdBPK_354050.1   protein kinase, putative
Leishmania infantum LinJ.35.4050   protein kinase, putative,MAP kinase kinase-like protein
Leishmania major LmjF.35.4000   protein kinase, putative,MAP kinase kinase-like protein
Leishmania mexicana LmxM.34.4000   protein kinase, putative,MAP kinase kinase-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Zea mays Casein kinase II alpha 332 aa 21.6% 268 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.1% 307 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.6% 279 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.7% 308 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.1% 290 aa Compounds References
Patiria pectinifera Cdc2 300 aa 24.5% 278 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.4% 299 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 29.8% 168 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0059 1 1
0.0069 0.3067 1
0.0091 1 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0092 1 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0008 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2614
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0066 0.3101 0
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0061 0.6883 0.5304
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 1
0.0032 0.5 0.5
0.0093 0.8828 0
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.2543
0.0064 0.3377 0
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.4000 (Leishmania major), protein kinase, putative,MAP kinase kinase-like protein
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