Detailed view for PVX_090090

Basic information

TDR Targets ID: 266158
Plasmodium vivax, CW-type zinc finger domain-containing protein
Source Database / ID:  PlasmoDB 

pI: 8.9042 | Length (AA): 3410 | MW (Da): 378594 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07496   CW-type Zinc Finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1929 2054 1amx () 183 318 20.00 0 0.19 0.1 -0.04
15 64 4qq4 (A) 406 453 50.00 0 1 0.632463 -0.69
721 772 4z0o (A) 23 77 46.00 0.0000003 0.95 0.486049 0.23
876 1031 3k29 (A) 7 162 9.00 0.53 0 0.157048 -0.51
895 1070 4uos (A) 2 184 8.00 0.73 0 0.136913 -0.65
2299 2414 1w9r (A) 5 119 21.00 0.8 0.05 0.354818 -1.17
2634 2897 1c1g (A) 6 264 16.00 0.015 0.01 0.209219 -0.12
2654 2835 3tiq (A) 438 628 30.00 0.51 0.02 0.0501724 1.15
2753 2912 4wik (A) 448 597 19.00 0.28 0.02 0.178721 -0.11
3313 3380 2dlk (A) 8 78 6.00 0.57 0 0.0662413 -0.56
3365 3401 2epy (A) 522 558 14.00 0.41 0.01 0.38715 -2.65
3366 3399 2emk (A) 8 41 12.00 0.0054 0.01 0.353271 -2.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_146909)

Species Accession Gene Product
Babesia bovis BBOV_III003470   CW-type zinc finger family protein
Caenorhabditis elegans CELE_C33G3.6   Protein C33G3.6
Plasmodium berghei PBANKA_0521300   zinc finger protein, putative
Plasmodium falciparum PF3D7_0420000   zinc finger protein, putative
Plasmodium knowlesi PKNH_0512700   zinc finger protein, putative
Plasmodium vivax PVX_090090   CW-type zinc finger domain-containing protein
Plasmodium yoelii PY05484   hypothetical protein
Schistosoma japonicum Sjp_0024010   expressed protein
Schistosoma japonicum Sjp_0204330   Conserved hypothetical protein
Schistosoma mansoni Smp_014610   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_090090 (Plasmodium vivax), CW-type zinc finger domain-containing protein
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