Detailed view for PF3D7_1435400

Basic information

TDR Targets ID: 2666
Plasmodium falciparum, ER membrane protein complex subunit 4, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.0382 | Length (AA): 190 | MW (Da): 21835 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06417   Protein of unknown function (DUF1077)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, merozoite, late schizont, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128239)

Species Accession Gene Product
Arabidopsis thaliana AT5G10780   hypothetical protein
Brugia malayi Bm1_32415   Hypothetical 21.5 kDa protein in SEC15-SAP4 intergenic region
Candida albicans CaO19_7183   hypothetical protein
Candida albicans CaO19.7183   similar to S. cerevisiae YGL231C
Caenorhabditis elegans CELE_ZK616.6   Protein PERM-3
Cryptosporidium hominis Chro.60137   multi-pass transmembrane protein
Cryptosporidium parvum cgd6_1070   conserved hypothetical protein
Dictyostelium discoideum DDB_G0295773   DUF1077 family protein
Drosophila melanogaster Dmel_CG11137   CG11137 gene product from transcript CG11137-RA
Echinococcus granulosus EgrG_000629300   transmembrane protein 85
Entamoeba histolytica EHI_012430   hypothetical protein, conserved
Entamoeba histolytica EHI_063570   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000629300   transmembrane protein 85
Leishmania braziliensis LbrM.30.1700   hypothetical protein, conserved
Leishmania donovani LdBPK_301660.1   Protein of unknown function (DUF1077), putative
Leishmania infantum LinJ.30.1660   hypothetical protein, conserved
Leishmania major LmjF.30.1645   hypothetical protein, conserved
Leishmania major LmjF.30.1650   hypothetical protein, conserved
Leishmania major LmjF.30.1625   hypothetical protein, conserved
Leishmania major LmjF.30.1660   hypothetical protein, conserved
Leishmania major LmjF.30.1630   hypothetical protein, conserved
Leishmania major LmjF.30.1640   hypothetical protein, conserved
Leishmania major LmjF.30.1635   hypothetical protein, conserved
Leishmania mexicana LmxM.29.1625   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02306   transmembrane protein 85
Mus musculus ENSMUSG00000027131   ER membrane protein complex subunit 4
Neospora caninum NCLIV_027490   hypothetical protein, conserved
Oryza sativa 4332886   Os03g0360500
Onchocerca volvulus OVOC3093   ER membrane protein complex subunit 4 homolog
Plasmodium berghei PBANKA_1009400   ER membrane protein complex subunit 4, putative
Plasmodium falciparum PF3D7_1435400   ER membrane protein complex subunit 4, putative
Plasmodium knowlesi PKNH_0422000   ER membrane protein complex subunit 4, putative
Plasmodium vivax PVX_084765   ER membrane protein complex subunit 4, putative
Saccharomyces cerevisiae YGL231C   Emc4p
Schistosoma japonicum Sjp_0306180   Transmembrane protein 85, putative
Schistosoma mansoni Smp_006340   hypothetical protein
Schmidtea mediterranea mk4.000379.05  
Trypanosoma brucei gambiense Tbg972.6.2360   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.2600   Protein of unknown function (DUF1077), putative
Trypanosoma cruzi TcCLB.509055.50   Protein of unknown function (DUF1077), putative
Trypanosoma cruzi TcCLB.509965.140   Protein of unknown function (DUF1077), putative
Toxoplasma gondii TGME49_259000   hypothetical protein

Essentiality

PF3D7_1435400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2600 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2600 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.2600 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.2600 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZK616.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK616.6 Caenorhabditis elegans larval arrest wormbase
CELE_ZK616.6 Caenorhabditis elegans sterile wormbase
PBANKA_1009400 Plasmodium berghei Essential plasmo
TGME49_259000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1435400 (Plasmodium falciparum), ER membrane protein complex subunit 4, putative
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