Detailed view for PVX_083445

Basic information

TDR Targets ID: 266824
Plasmodium vivax, phosphatidylinositol transfer protein, putative
Source Database / ID:  PlasmoDB 

pI: 5.9432 | Length (AA): 932 | MW (Da): 103499 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02121   Phosphatidylinositol transfer protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005548   phospholipid transporter activity  
GO:0005622   intracellular  
GO:0015914   phospholipid transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 266 2a1l (A) 2 260 32.00 0 1 0.69 -0.67
1 268 1t27 (A) 2 263 29.00 0 1 0.604654 -0.11
1 264 2a1l (A) 2 258 32.00 0 1 0.635462 -0.23
390 484 2jzv (A) 0 235 34.00 0.61 0.3 0.284231 0.53
413 521 4ke2 (A) 21 126 26.00 0.44 0.03 0.413253 -0.58
774 919 3wbz (A) 51 198 21.00 0.92 0.87 0.355952 0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_132657)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG17818   CG17818 gene product from transcript CG17818-RA
Homo sapiens ENSG00000154217   phosphatidylinositol transfer protein, cytoplasmic 1
Mus musculus ENSMUSG00000040430   phosphatidylinositol transfer protein, cytoplasmic 1
Oryza sativa 4332482   Os03g0287100
Plasmodium falciparum PF3D7_1351000   phosphatidylinositol transfer protein, putative
Plasmodium knowlesi PKNH_1249900   phosphatidylinositol transfer protein, putative
Plasmodium vivax PVX_083445   phosphatidylinositol transfer protein, putative
Theileria parva TP02_0715   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_083445 (Plasmodium vivax), phosphatidylinositol transfer protein, putative
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