Detailed view for PVX_093625

Basic information

TDR Targets ID: 266924
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 8.0003 | Length (AA): 1068 | MW (Da): 119597 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF04003   Dip2/Utp12 Family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 277 1got (B) 49 340 13.00 0 0.6 0.37 -0.67
13 363 1nr0 (A) 16 389 11.00 0.000000061 1 0.37 0.01
393 891 1pgu (A) 3 440 13.00 0.00000000087 0.92 0.35 0.68
7 67 4cy3 (A) 108 169 16.00 0.038 0.18 0.277316 -0.68
119 234 4a11 (B) 248 361 29.00 0.042 0.99 0.411414 0.31
162 687 2ymu (A) 15 539 24.00 0.000000044 1 0.497309 1
418 479 3vl1 (A) 145 206 32.00 0.022 0.51 0.458852 -0.35
553 595 3jro (A) 41 82 45.00 0.16 0.15 0.327062 1.53
942 971 2eqw (A) 409 438 10.00 0.0087 0 -0.18421 2.94
998 1027 2epc (A) 241 270 17.00 0.54 0.02 0.30679 -1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128106)

Species Accession Gene Product
Arabidopsis thaliana AT1G15440   periodic tryptophan protein 2
Babesia bovis BBOV_II001010   periodic tryptophan protein 2-like protein, putative
Brugia malayi Bm1_08665   Periodic tryptophan protein 2 homolog
Candida albicans CaO19.3276   bud-site selection, cell polarity, cytokinesis
Candida albicans CaO19.10786   bud-site selection, cell polarity, cytokinesis
Caenorhabditis elegans CELE_F55F8.3   Protein F55F8.3
Cryptosporidium hominis Chro.20305   WD repeat protein
Cryptosporidium parvum cgd2_2910   large WD repeat protein
Dictyostelium discoideum DDB_G0284621   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG12325   CG12325 gene product from transcript CG12325-RB
Echinococcus granulosus EgrG_000886300   periodic tryptophan protein 2
Entamoeba histolytica EHI_151370   WD domain containing protein
Echinococcus multilocularis EmuJ_000886300   periodic tryptophan protein 2
Giardia lamblia GL50803_94653   Periodic tryptophan protein 2-like protein
Homo sapiens ENSG00000275464   periodic tryptophan protein 2 homolog
Homo sapiens ENSG00000241945   PWP2 periodic tryptophan protein homolog (yeast)
Leishmania braziliensis LbrM.18.0920   periodic tryptophan protein 2-like protein
Leishmania donovani LdBPK_180830.1   Periodic tryptophan protein 2 homolog, putative
Leishmania infantum LinJ.18.0830   periodic tryptophan protein 2-like protein
Leishmania major LmjF.18.0830   periodic tryptophan protein 2-like protein
Leishmania mexicana LmxM.18.0830   periodic tryptophan protein 2-like protein
Loa Loa (eye worm) LOAG_02916   hypothetical protein
Loa Loa (eye worm) LOAG_12593   wd-repeat protein
Mus musculus ENSMUSG00000032834   PWP2 periodic tryptophan protein homolog (yeast)
Neospora caninum NCLIV_002140   WD repeat protein, related
Oryza sativa 4339341   Os05g0519500
Onchocerca volvulus OVOC13466  
Onchocerca volvulus OVOC7856   Periodic tryptophan protein 2 homolog
Plasmodium berghei PBANKA_1227900   periodic tryptophan protein 2, putative
Plasmodium falciparum PF3D7_0802300   periodic tryptophan protein 2, putative
Plasmodium knowlesi PKNH_0116600   periodic tryptophan protein 2, putative
Plasmodium vivax PVX_093625   hypothetical protein, conserved
Plasmodium yoelii PY04284   WD-repeat protein p103
Saccharomyces cerevisiae YCR057C   Pwp2p
Schistosoma japonicum Sjp_0118270   Periodic tryptophan protein 2 homolog, putative
Schistosoma japonicum Sjp_0128350   Periodic tryptophan protein 2 homolog, putative
Schistosoma japonicum Sjp_0125030   Periodic tryptophan protein 2 homolog, putative
Schistosoma japonicum Sjp_0128210   Periodic tryptophan protein 2 homolog, putative
Schistosoma japonicum Sjp_0119730   Periodic tryptophan protein 2 homolog, putative
Schistosoma japonicum Sjp_0212000   IPR007190,Periodic tryptophan protein-associated region,domain-containing
Schistosoma japonicum Sjp_0117560   expressed protein
Schistosoma mansoni Smp_126910   hypothetical protein
Schmidtea mediterranea mk4.004114.05   Periodic tryptophan protein 2 homolog
Schmidtea mediterranea mk4.004114.06  
Schmidtea mediterranea mk4.004114.04   Periodic tryptophan protein 2 homolog
Schmidtea mediterranea mk4.018422.00   Periodic tryptophan protein 2 homolog
Trypanosoma brucei gambiense Tbg972.10.16040   periodic tryptophan protein 2, putative,predicted WD40 repeat protein
Trypanosoma brucei Tb11.v5.0563   periodic tryptophan protein 2, putative
Trypanosoma congolense TcIL3000_10_11360   Periodic tryptophan protein 2 homolog, putative
Trypanosoma cruzi TcCLB.506357.140   Periodic tryptophan protein 2 homolog, putative
Toxoplasma gondii TGME49_295680   periodic tryptophan protein PWP2, putative
Theileria parva TP04_0485   hypothetical protein, conserved
Trichomonas vaginalis TVAG_166140   WD repeat domain, putative

Essentiality

PVX_093625 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13270 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.13270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.13270 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13270 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F55F8.3 Caenorhabditis elegans larval arrest wormbase
CELE_F55F8.3 Caenorhabditis elegans larval lethal wormbase
CELE_F55F8.3 Caenorhabditis elegans sterile wormbase
YCR057C Saccharomyces cerevisiae inviable yeastgenome
TGME49_295680 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_093625 (Plasmodium vivax), hypothetical protein, conserved
Title for this comment
Comment