Detailed view for PVX_091820

Basic information

TDR Targets ID: 266931
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 6.7702 | Length (AA): 1497 | MW (Da): 168540 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02138   Beige/BEACH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
360 760 1mi1 (A) 2151 2550 33.00 0 1 0.55 -0.55
108 334 4tql (A) 9 234 10.00 0.014 0.12 0.182837 -0.6
354 763 1mi1 (A) 2145 2553 31.00 0 1 0.377081 0.26
354 763 1t77 (A) 2081 2489 31.00 0 1 0.364081 0.19
1087 1374 1erj (A) 338 705 18.00 0.00000057 0.97 0.180585 0.68
1126 1235 3sfz (A) 641 760 34.00 0.98 0.92 0.31728 0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_130409)

Species Accession Gene Product
Babesia bovis BBOV_IV002430   factor associated with neutral-sphingomyelinase activation
Cryptosporidium hominis Chro.40385   hypothetical protein
Cryptosporidium parvum cgd4_3390   neutral sphingomyelinase activation associated factor-like BEACH domain containing protein
Dictyostelium discoideum DDB_G0284333   BEACH domain-containing protein
Entamoeba histolytica EHI_056360   hypothetical protein, conserved domain containing
Homo sapiens ENSG00000035681   neutral sphingomyelinase (N-SMase) activation associated factor
Leishmania braziliensis LbrM.23.1810   neutral sphingomyelinase activation associated factor-like protein
Leishmania donovani LdBPK_231970.1   neutral sphingomyelinase activation associated factor-like protein
Leishmania infantum LinJ.23.1970   neutral sphingomyelinase activation associated factor-like protein
Leishmania major LmjF.23.1570   neutral sphingomyelinase activation associated factor-like protein
Leishmania mexicana LmxM.23.1570   neutral sphingomyelinase activation associated factor-like protein
Mus musculus ENSMUSG00000028245   neutral sphingomyelinase (N-SMase) activation associated factor
Neospora caninum NCLIV_024920   hypothetical protein
Plasmodium berghei PBANKA_0924200   beige/BEACH domain protein, putative
Plasmodium falciparum PF3D7_1124100   beige/BEACH domain protein, putative
Plasmodium knowlesi PKNH_0921900   beige/BEACH domain protein, putative
Plasmodium vivax PVX_091820   hypothetical protein, conserved
Plasmodium yoelii PY01158   protein factor associated with neutral-sphingomyelinase activation
Toxoplasma gondii TGME49_263000   Beige/BEACH domain-containing protein
Theileria parva TP03_0409   hypothetical protein

Essentiality

PVX_091820 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_263000 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_091820 (Plasmodium vivax), hypothetical protein, conserved
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