pI: 8.4477 |
Length (AA): 1048 |
MW (Da): 118738 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 817 | 1w36 (B) | 6 | 735 | 17.00 | 0 | 1 | 0.66 | 1.37 |
31 | 397 | 3u4q (A) | 20 | 426 | 26.00 | 0.000059 | 0.89 | 0.355191 | 1.26 |
346 | 1018 | 4c2u (A) | 195 | 618 | 33.00 | 0.000000000011 | 1 | 0.237176 | 1.67 |
600 | 1047 | 1pjr (A) | 177 | 642 | 15.00 | 0.00000092 | 0.81 | 0.567381 | 0.27 |
674 | 715 | 4zu2 (A) | 39 | 82 | 43.00 | 0.6 | 0.32 | 0.355076 | 0.99 |
1008 | 1040 | 2adr (A) | 102 | 134 | 30.00 | 0.39 | 0.13 | 0.0817885 | 2.38 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 30 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 12 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_127542)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G25120 | helicase SRS2-like protein |
Candida albicans | CaO19.13391 | similar to S. cerevisiae HPR5 (YJL092W) DNA helicase involved in double strand break repair |
Candida albicans | CaO19.5970 | similar to S. cerevisiae HPR5 (YJL092W) DNA helicase involved in double strand break repair |
Cryptosporidium hominis | Chro.80373 | helicase-like protein nhl |
Cryptosporidium parvum | cgd8_3210 | UvrD like super family I helicase involved in nucleotide excision repair, possible bacterial horizontal transfer |
Chlamydia trachomatis | CT_608 | DNA helicase |
Escherichia coli | b3813 | DNA-dependent ATPase I and helicase II |
Escherichia coli | b3778 | DNA helicase and single-stranded DNA-dependent ATPase |
Leishmania braziliensis | LbrM.09.0670 | ATP-dependent DNA helicase, putative |
Leishmania donovani | LdBPK_090640.1 | ATP-dependent DNA helicase, putative |
Leishmania infantum | LinJ.09.0640 | ATP-dependent DNA helicase, putative |
Leishmania major | LmjF.09.0590 | ATP-dependent DNA helicase, putative |
Leishmania mexicana | LmxM.09.0590 | ATP-dependent DNA helicase, putative |
Mycobacterium leprae | ML0153 | Probable ATP dependent DNA helicase UvrD1 |
Mycobacterium tuberculosis | Rv0949 | Probable ATP-dependent DNA helicase II UvrD1 |
Mycobacterium ulcerans | MUL_4723 | ATP-dependent DNA helicase II UvrD1 |
Oryza sativa | 4343276 | Os07g0492100 |
Plasmodium berghei | PBANKA_1113800 | ATP-dependent DNA helicase UvrD, putative |
Plasmodium falciparum | PF3D7_0514100 | ATP-dependent DNA helicase UvrD |
Plasmodium knowlesi | PKNH_1019000 | ATP-dependent DNA helicase UvrD, putative |
Plasmodium vivax | PVX_080535 | ATP-dependent DNA helicase UvrD, putative |
Plasmodium yoelii | PY02817 | probable DNA helicase ii homolog |
Plasmodium yoelii | PY01998 | hypothetical protein |
Saccharomyces cerevisiae | YJL092W | Srs2p |
Schmidtea mediterranea | mk4.043254.00 | |
Trypanosoma brucei gambiense | Tbg972.11.14060 | ATP-dependent DNA helicase, putative |
Trypanosoma brucei | Tb927.11.12600 | ATP-dependent DNA helicase, putative |
Trypanosoma congolense | TcIL3000_0_58020 | ATP-dependent DNA helicase, putative |
Trypanosoma cruzi | TcCLB.508777.90 | ATP-dependent DNA helicase, putative |
Trypanosoma cruzi | TcCLB.509029.120 | ATP-dependent DNA helicase, putative |
Treponema pallidum | TP0102 | rep helicase, single-stranded DNA-dependent ATPase (rep) |
Treponema pallidum | TP1028 | DNA helicase II (uvrD) |
Trichomonas vaginalis | TVAG_296350 | ATP-dependent DNA helicase rep, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0628 | superfamily I DNA/RNA helicase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu964 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.4440 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4440 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4440 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.4440 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3778 | Escherichia coli | non-essential | goodall |
b3813 | Escherichia coli | non-essential | goodall |
PBANKA_1113800 | Plasmodium berghei | Dispensable | plasmo |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.