pI: 4.1962 |
Length (AA): 149 |
MW (Da): 17029 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
114 | 190 | 1i4k (A) | 3 | 74 | 22.00 | 0 | 1 | 0.58 | -1.55 |
116 | 190 | 1d3b (A) | 6 | 75 | 16.00 | 0.0000000026 | 0.96 | 0.66 | -1.96 |
8 | 81 | 4c92 (E) | 7 | 83 | 28.00 | 0.000011 | 0.99 | 0.918144 | -0.93 |
8 | 81 | 3pgg (A) | 28 | 111 | 22.00 | 0.0000055 | 1 | 0.829144 | -0.33 |
11 | 70 | 1i8f (A) | 14 | 73 | 28.00 | 0.1 | 0.92 | 0.804085 | -0.36 |
11 | 82 | 1i8f (A) | 14 | 79 | 35.00 | 0.000026 | 1 | 0.901821 | -0.65 |
15 | 130 | 4c92 (A) | 48 | 162 | 28.00 | 0 | 0.93 | 1.21502 | -0.74 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 40 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128760)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G19120 | Small nuclear ribonucleoprotein family protein |
Arabidopsis thaliana | AT3G14080 | U6 snRNA-associated Sm-like protein LSm1 |
Babesia bovis | BBOV_IV008340 | LSM domain containing protein |
Brugia malayi | Bm1_14415 | U6 snRNA-associated Sm-like protein LSm |
Candida albicans | CaO19.7290 | Sm-like protein similar to S. cerevisiae LSM1 (YJL124C) part of a cytoplasmic complex that activates the decapping step of mRNA |
Caenorhabditis elegans | CELE_F40F8.9 | Protein LSM-1 |
Cryptosporidium hominis | Chro.50482 | hypothetical protein |
Cryptosporidium parvum | cgd5_3710 | small nuclear ribonucleoprotein U6 |
Dictyostelium discoideum | DDB_G0279837 | LSM domain-containing protein |
Drosophila melanogaster | Dmel_CG4279 | CG4279 gene product from transcript CG4279-RA |
Echinococcus granulosus | EgrG_000444500 | u6 snRNA associated Sm protein LSm1 |
Echinococcus multilocularis | EmuJ_000444500 | u6 snRNA associated Sm protein LSm1 |
Homo sapiens | ENSG00000175324 | LSM1, U6 small nuclear RNA associated |
Loa Loa (eye worm) | LOAG_08792 | U6 snRNA-associated Sm-family protein LSm |
Mus musculus | ENSMUSG00000037296 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
Neospora caninum | NCLIV_005690 | hypothetical protein |
Oryza sativa | 4335963 | Os04g0445800 |
Plasmodium berghei | PBANKA_0923900 | U6 snRNA-associated Sm-like protein LSm1, putative |
Plasmodium falciparum | PF3D7_1124400 | U6 snRNA-associated Sm-like protein LSm1, putative |
Plasmodium knowlesi | PKNH_0922200 | U6 snRNA-associated Sm-like protein LSm1, putative |
Plasmodium vivax | PVX_091835 | LSM domain containing protein |
Saccharomyces cerevisiae | YJL124C | Lsm1p |
Schistosoma japonicum | Sjp_0307150 | U6 snRNA-associated Sm-like protein LSm1, putative |
Schmidtea mediterranea | mk4.006386.00 | |
Toxoplasma gondii | TGME49_222290 | LSM domain-containing protein |
Theileria parva | TP01_0940 | hypothetical protein |
Trichomonas vaginalis | TVAG_281550 | lsm1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F40F8.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F40F8.9 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_222290 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.