Detailed view for PVX_091755

Basic information

TDR Targets ID: 267560
Plasmodium vivax, calcium-dependent protein kinase 6, putative
Source Database / ID:  PlasmoDB 

pI: 5.8609 | Length (AA): 1607 | MW (Da): 183624 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF13202   EF hand

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
984 1501 1omw (A) 30 552 19.00 0 1 0.38 0.02
1005 1417 1k9a (A) 26 442 18.00 0 1 0.27 0.05
1212 1421 1cm8 (A) 74 312 35.00 0 1 0.52 -1.8
1 104 2fxo (A) 859 963 12.00 0.38 0 0.182517 -0.32
6 178 5cwk (A) 3 172 15.00 0.43 0.04 0.295454 -0.78
1064 1449 4w7p (A) 6 371 24.00 0 1 0.313099 0.85
1138 1606 3lij (A) 38 512 32.00 0 1 0.647748 -0.38
1159 1422 3is5 (A) 126 395 50.00 0 1 0.696181 -0.24
1429 1607 3mse (B) 1 179 76.00 0 1 0.972688 -0.8
1464 1523 4gft (A) 140 199 17.00 0.024 0.99 0.407237 -1.53
1469 1539 1gjy (A) 106 176 20.00 0.008 0.52 0.339082 -1.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3MSE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_146625)

Species Accession Gene Product
Cryptosporidium hominis Chro.40377   hypothetical protein
Cryptosporidium parvum cgd4_3330   hypothetical protein
Neospora caninum NCLIV_061660   CAM kinase, CDPK family, putative
Plasmodium berghei PBANKA_0925500   calcium-dependent protein kinase 6
Plasmodium falciparum PF3D7_1122800   calcium-dependent protein kinase 6
Plasmodium knowlesi PKNH_0920600   calcium-dependent protein kinase 6, putative
Plasmodium vivax PVX_091755   calcium-dependent protein kinase 6, putative
Plasmodium yoelii PY04265   Plasmodium falciparum CDPK2 protein-related
Toxoplasma gondii TGME49_218720   calcium-dependent protein kinase CDPK6

Essentiality

PVX_091755 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0925500 Plasmodium berghei Slow plasmo
TGME49_218720 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.3% 289 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.0% 239 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.4% 156 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 28.1% 292 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 25.9% 301 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.5% 246 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.3% 293 aa Compounds References
Zea mays CaM kinase I alpha 492 aa 29.7% 414 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0012 0.5 0.5
0.0067 0.5 0.5
0.0011 1 0.5
0.0091 1 0.5
0.0037 1 0.5
0.0059 1 1
0.0066 0.3101 0.5
0.0081 1 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.2614
0.0081 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0036 0.5 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0029 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.7244
0.0003 0.5 0.5
0.0033 1 1
0.0026 0.5 0.5
0.0062 0.6935 0.5
0.0004 0.5 0.5
0.0064 0.3377 0.5
0.0008 0.5 0.5
0.0027 1 0.5
0.0022 0.5 0.5
0.0061 0.6883 1
0.0018 0.5 0.5
0.0069 0.3067 1
0.0039 0.5 0.5
0.0093 0.8828 0
0.0063 1 1
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0042 0.5 0.5
0.0088 0.4477 0.5
0.0023 0.5 0.5
0.0056 1 0.5
0.0012 0.5 0.5
0.0092 1 0.5
0.0039 0.9485 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_091755 (Plasmodium vivax), calcium-dependent protein kinase 6, putative
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