pI: 4.8573 |
Length (AA): 565 |
MW (Da): 65336 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 228 | 1hu3 (A) | 1 | 984 | 15.00 | 0 | 0.99 | 0.47 | -0.85 |
27 | 230 | 1hu3 (A) | 746 | 986 | 13.00 | 0 | 0.8 | 0.45 | -1.04 |
2 | 290 | 4c9b (B) | 131 | 406 | 30.00 | 0 | 1 | 0.910104 | -1.02 |
53 | 229 | 2i2o (A) | 19 | 207 | 11.00 | 0.000031 | 0.39 | 0.453474 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127721)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G80930 | MIF4G and MA3 domain-containing protein |
Babesia bovis | BBOV_IV006530 | MIF4G/MA3 domains containing protein |
Brugia malayi | Bm1_44100 | hypothetical protein |
Candida albicans | CaO19.1771 | similar to S. pombe Cdf22 (SPBC13E7.01) and S. cerevisiae CWC22 (YGR278W) spliceosome associated protein, complexed with Myb-rel |
Candida albicans | CaO19.9340 | similar to S. pombe Cdf22 (SPBC13E7.01) and S. cerevisiae CWC22 (YGR278W) spliceosome associated protein, complexed with Myb-rel |
Caenorhabditis elegans | CELE_F33A8.1 | Protein LET-858 |
Cryptosporidium hominis | Chro.80346 | hypothetical protein |
Cryptosporidium hominis | Chro.80345 | cell cycle control protein cwf22 |
Cryptosporidium parvum | cgd8_2960 | NIC+MI domains containing protein. nucampholin/yeast Cwc22p like protein involved in mRNA splicing |
Dictyostelium discoideum | DDB_G0267796 | initiation factor eIF-4 gamma middle domain-containing protein |
Drosophila melanogaster | Dmel_CG12750 | nucampholin |
Echinococcus granulosus | EgrG_000529100 | pre mRNA splicing factor CWC22 |
Entamoeba histolytica | EHI_093720 | cell cycle control protein, putative |
Echinococcus multilocularis | EmuJ_000529100 | pre mRNA splicing factor CWC22 |
Homo sapiens | ENSG00000163510 | CWC22 spliceosome-associated protein |
Leishmania braziliensis | LbrM.35.5410 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_365390.1 | pre-mRNA-splicing factor CWC22, putative |
Leishmania infantum | LinJ.36.5390 | hypothetical protein, conserved |
Leishmania major | LmjF.36.5160 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.5160 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_13454 | pre-mRNA-splicing factor CWC22 |
Loa Loa (eye worm) | LOAG_06258 | TK/FER protein kinase |
Mus musculus | ENSMUSG00000027014 | CWC22 spliceosome-associated protein homolog (S. cerevisiae) |
Neospora caninum | NCLIV_009840 | cell cycle control protein, putative |
Oryza sativa | 4351904 | Os12g0256300 |
Onchocerca volvulus | OVOC7 |
|
Plasmodium berghei | PBANKA_1452800 | pre-mRNA-splicing factor CWC22, putative |
Plasmodium falciparum | PF3D7_1238300 | pre-mRNA-splicing factor CWC22, putative |
Plasmodium knowlesi | PKNH_1458100 | pre-mRNA-splicing factor CWC22, putative |
Plasmodium vivax | PVX_100865 | cell cycle control protein, putative |
Plasmodium yoelii | PY04825 | Drosophila melanogaster GH13383p |
Saccharomyces cerevisiae | YGR278W | Cwc22p |
Schistosoma japonicum | Sjp_0115020 | Nucampholin homolog, putative |
Schistosoma mansoni | Smp_171070 | cell cycle control protein cwf22 |
Schmidtea mediterranea | mk4.006963.02 | |
Schmidtea mediterranea | mk4.007088.01 | Pre-mRNA-splicing factor CWC22 homolog |
Schmidtea mediterranea | mk4.010305.00 | Pre-mRNA-splicing factor CWC22 homolog |
Schmidtea mediterranea | mk4.002298.00 | Pre-mRNA-splicing factor CWC22 homolog |
Trypanosoma brucei gambiense | Tbg972.11.12040 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.10750 | pre-mRNA-splicing factor CWC22, putative |
Trypanosoma congolense | TcIL3000.11.11410 | pre-mRNA-splicing factor CWC22, putative |
Trypanosoma cruzi | TcCLB.506155.40 | pre-mRNA-splicing factor CWC22, putative |
Toxoplasma gondii | TGME49_320430 | cell-cycle-control protein (translation regulation), putative |
Theileria parva | TP01_1202 | cell cycle control protein, putative |
Trichomonas vaginalis | TVAG_493850 | cell cycle control protein cwf22, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.2520 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2520 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2520 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.2520 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F33A8.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F33A8.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F33A8.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F33A8.1 | Caenorhabditis elegans | sterile | wormbase |
YGR278W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1452800 | Plasmodium berghei | Essential | plasmo |
TGME49_320430 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.