Detailed view for PVX_084330

Basic information

TDR Targets ID: 268467
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 5.7955 | Length (AA): 1193 | MW (Da): 132107 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05277   Protein of unknown function (DUF726)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
789 870 1zzp (A) 36 115 15.00 0.0000012 0.04 0.27 -0.84
308 451 4uos (A) 0 143 15.00 0.11 0.14 0.261004 -0.39
383 601 5cwp (A) 5 225 14.00 0.37 0.02 0.369871 -0.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 24 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128851)

Species Accession Gene Product
Arabidopsis thaliana AT2G18100   hypothetical protein
Arabidopsis thaliana AT4G36210   hypothetical protein
Babesia bovis BBOV_IV002030   conserved hypothetical protein
Brugia malayi Bm1_43710   RIKEN cDNA 4632413C14
Candida albicans CaO19.2574   same as cosmid orf Ca49C4.05c
Candida albicans CaO19.10106   same as cosmid orf Ca49C4.05c
Caenorhabditis elegans CELE_F35D11.3   Protein F35D11.3
Cryptosporidium hominis Chro.40151   hypothetical protein
Cryptosporidium parvum cgd4_1320   hypothetical protein
Dictyostelium discoideum DDB_G0275413   DUF726 family protein
Dictyostelium discoideum DDB_G0277789   DUF726 family protein
Homo sapiens ENSG00000162542   transmembrane and coiled-coil domains 4
Loa Loa (eye worm) LOAG_03591   hypothetical protein
Mus musculus ENSMUSG00000041143   transmembrane and coiled-coil domains 4
Neospora caninum NCLIV_021650   hypothetical protein
Oryza sativa 4331373   Os03g0112800
Oryza sativa 9269754   Os10g0512100
Onchocerca volvulus OVOC10615  
Plasmodium berghei PBANKA_0604600   conserved protein, unknown function
Plasmodium falciparum PF3D7_1205900   conserved protein, unknown function
Plasmodium knowlesi PKNH_1305600   conserved protein, unknown function
Plasmodium vivax PVX_084330   hypothetical protein, conserved
Plasmodium yoelii PY07444   hypothetical protein
Saccharomyces cerevisiae YFL034W   hypothetical protein
Toxoplasma gondii TGME49_203300   hypothetical protein
Theileria parva TP03_0450   hypothetical protein

Essentiality

PVX_084330 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_203300 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_084330 (Plasmodium vivax), hypothetical protein, conserved
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