Detailed view for PVX_114475

Basic information

TDR Targets ID: 268525
Plasmodium vivax, mitochondrial import inner membrane translocase subunit TIM22, putative
Source Database / ID:  PlasmoDB 

pI: 9.4916 | Length (AA): 183 | MW (Da): 20700 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02466   Tim17/Tim22/Tim23/Pmp24 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005743   mitochondrial inner membrane  
GO:0008565   protein transporter activity  
GO:0015031   protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128586)

Species Accession Gene Product
Arabidopsis thaliana AT3G10110   mitochondrial import inner membrane translocase subunit TIM22-1
Arabidopsis thaliana AT1G18320   mitochondrial import inner membrane translocase subunit TIM22-4
Babesia bovis BBOV_IV002410   mitochondrial import inner membrane translocase subunit Tim17, putative
Brugia malayi Bm1_42185   Mitochondrial import inner membrane translocase subunit Tim17 family protein
Candida albicans CaO19.1352   Mitochondrial inner membrane protein.
Candida albicans CaO19.8932   Mitochondrial inner membrane protein.
Candida albicans CaO19.2658   mitochondrial inner membrane protein.
Caenorhabditis elegans CELE_C47G2.3   Protein C47G2.3
Dictyostelium discoideum DDB_G0283865   hypothetical protein
Drosophila melanogaster Dmel_CG31229   CG31229 gene product from transcript CG31229-RA
Echinococcus granulosus EgrG_000773900   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_000773900   mitochondrial import inner membrane translocase
Homo sapiens 29928   translocase of inner mitochondrial membrane 22 homolog (yeast)
Leishmania braziliensis LbrM.09.1180   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania donovani LdBPK_091190.1   mitochondrial import inner membrane translocase subunit TIM17, putative
Leishmania infantum LinJ.09.1190   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania major LmjF.09.1130   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania mexicana LmxM.09.1130   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Mus musculus ENSMUSG00000020843   translocase of inner mitochondrial membrane 22
Neospora caninum NCLIV_047100   hypothetical protein
Oryza sativa 4332537   Os03g0296300
Plasmodium berghei PBANKA_1126100   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium falciparum PF3D7_0627400   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium knowlesi PKNH_1122400   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium vivax PVX_114475   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium yoelii PY04639   mitochondrial import inner membrane translocase subunit tim22 homolog
Saccharomyces cerevisiae YDL217C   Tim22p
Schistosoma japonicum Sjp_0020600   Mitochondrial import inner membrane translocase subunit Tim22, putative
Schistosoma mansoni Smp_038630   mitochondrial import inner membrane translocase subunit tim22
Schmidtea mediterranea mk4.000142.05   Putative mitochondrial import inner membrane translocase subunit tim22
Trypanosoma brucei gambiense Tbg972.11.14830   inner membrane preprotein translocase Tim17, putative
Trypanosoma brucei Tb927.11.13290   mitochondrial import inner membrane translocase subunit tim17
Trypanosoma congolense TcIL3000.11.13660   mitochondrial import inner membrane translocase subunit tim17
Trypanosoma cruzi TcCLB.510359.260   mitochondrial import inner membrane translocase subunit TIM17, putative
Trypanosoma cruzi TcCLB.506755.250   mitochondrial import inner membrane translocase subunit TIM17, putative
Toxoplasma gondii TGME49_225710   mitochondrial inner membrane translocase subunit TIM17, putative
Theileria parva TP03_0412   hypothetical protein

Essentiality

PVX_114475 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4870 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4870 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.4870 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.4870 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C47G2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C47G2.3 Caenorhabditis elegans sterile wormbase
YDL217C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1126100 Plasmodium berghei Essential plasmo
TGME49_225710 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PVX_114475 (Plasmodium vivax), mitochondrial import inner membrane translocase subunit TIM22, putative
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