Detailed view for PVX_089750

Basic information

TDR Targets ID: 268896
Plasmodium vivax, 60S ribosomal protein L15-1, putative
Source Database / ID:  PlasmoDB 

pI: 11.9302 | Length (AA): 205 | MW (Da): 24194 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00827   Ribosomal L15

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 195 1jj2 (L) 3 193 43.00 0 1 1.32 0.42
2 198 1ffk (I) 3 194 43.00 0 1 1.35138 1.11
2 195 1vq8 (M) 3 193 43.00 0 1 1.36974 0.15
37 68 2jy9 (A) 105 137 44.00 0.53 0.08 0.328498 2.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_127033)

Species Accession Gene Product
Arabidopsis thaliana AT4G16720   60S ribosomal protein L15-1
Arabidopsis thaliana AT4G17390   60S ribosomal protein L15-2
Babesia bovis BBOV_III000550   ribosomal protein L15, putative
Brugia malayi Bm1_20955   60S ribosomal protein L15
Candida albicans CaO19.8123   likely cytosolic ribosomal protein similar to S. cerevisiae RPL15B (YMR121C) large subunit protein L15
Candida albicans CaO19.493   likely cytosolic ribosomal protein similar to S. cerevisiae RPL15B (YMR121C) large subunit protein L15
Caenorhabditis elegans CELE_K11H12.2   Protein RPL-15
Cryptosporidium hominis Chro.20035   60S ribosomal protein L15-2
Cryptosporidium parvum cgd2_280   60S ribosomal protein L15
Dictyostelium discoideum DDB_G0272893   S60 ribosomal protein L15
Dictyostelium discoideum DDB_G0273983   S60 ribosomal protein L15
Drosophila melanogaster Dmel_CG17420   Ribosomal protein L15
Echinococcus granulosus EgrG_000252800   ribosomal protein L15
Entamoeba histolytica EHI_040800   60S ribosomal protein L15, putative
Entamoeba histolytica EHI_020300   60S ribosomal protein L15, putative
Echinococcus multilocularis EmuJ_000252800   ribosomal protein L15
Giardia lamblia GL50803_8001   Ribosomal protein L15
Homo sapiens ENSG00000174748   ribosomal protein L15
Leishmania braziliensis LbrM.34.1810   ribosomal protein L15, putative
Leishmania braziliensis LbrM.30.3680   ribosomal protein L15, putative
Leishmania donovani LdBPK_351890.1   ribosomal protein L15, putative
Leishmania donovani LdBPK_303710.1   ribosomal protein L15, putative
Leishmania infantum LinJ.30.3710   ribosomal protein L15, putative
Leishmania infantum LinJ.35.1890   ribosomal protein L15, putative
Leishmania major LmjF.35.1910   ribosomal protein L15, putative
Leishmania major LmjF.30.3650   ribosomal protein L15, putative
Leishmania mexicana LmxM.29.3650   ribosomal protein L15, putative
Leishmania mexicana LmxM.34.1910   ribosomal protein L15, putative
Loa Loa (eye worm) LOAG_12612   hypothetical protein
Mus musculus ENSMUSG00000012405   ribosomal protein L15
Mus musculus 102641848   60S ribosomal protein L15-like
Mus musculus 100043670   predicted gene 4581
Neospora caninum NCLIV_045010   hypothetical protein
Oryza sativa 9266562   Os05g0274700
Oryza sativa 4333387   Os03g0598800
Plasmodium berghei PBANKA_0717800   60S ribosomal protein L15, putative
Plasmodium falciparum PF3D7_0415900   60S ribosomal protein L15, putative
Plasmodium knowlesi PKNH_0507500   60S ribosomal protein L15, putative
Plasmodium vivax PVX_089750   60S ribosomal protein L15-1, putative
Plasmodium yoelii PY02811   Ribosomal L15
Saccharomyces cerevisiae YLR029C   ribosomal 60S subunit protein L15A
Saccharomyces cerevisiae YMR121C   ribosomal 60S subunit protein L15B
Schistosoma japonicum Sjp_0305630   ko:K02877 large subunit ribosomal protein L15e, putative
Schistosoma mansoni Smp_032260   ribosomal protein L15
Schmidtea mediterranea mk4.001588.04   Ribosomal protein L15
Trypanosoma brucei gambiense Tbg972.9.9400   ribosomal protein L15, putative
Trypanosoma brucei gambiense Tbg972.6.4840   ribosomal protein L15, putative
Trypanosoma brucei Tb927.9.15190   ribosomal protein L15, putative
Trypanosoma congolense TcIL3000_9_6350   ribosomal protein L15, putative
Trypanosoma congolense TcIL3000_6_4470   ribosomal protein L15, putative
Trypanosoma cruzi TcCLB.509671.70   ribosomal protein L15, putative
Trypanosoma cruzi TcCLB.506945.290   ribosomal protein L15, putative
Trypanosoma cruzi TcCLB.510767.10   ribosomal protein L15, putative
Toxoplasma gondii TGME49_228470   ribosomal protein RPL15
Theileria parva TP03_0755   60S ribosomal protein L15, putative
Trichomonas vaginalis TVAG_200220   60S ribosomal protein L15, putative
Trichomonas vaginalis TVAG_159780   50S ribosomal protein L15e, putative
Trichomonas vaginalis TVAG_276360   60S ribosomal protein L15, putative
Trichomonas vaginalis TVAG_148950   50S ribosomal protein L15e, putative

Essentiality

PVX_089750 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.5040 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.5040 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.5040 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.5040 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K11H12.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K11H12.2 Caenorhabditis elegans larval arrest wormbase
CELE_K11H12.2 Caenorhabditis elegans larval lethal wormbase
CELE_K11H12.2 Caenorhabditis elegans slow growth wormbase
CELE_K11H12.2 Caenorhabditis elegans sterile wormbase
YLR029C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0717800 Plasmodium berghei Essential plasmo
TGME49_228470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_089750 (Plasmodium vivax), 60S ribosomal protein L15-1, putative
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