pI: 6.0957 |
Length (AA): 548 |
MW (Da): 62937 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
202 | 354 | 1l3i (A) | 16 | 152 | 13.00 | 0.0000004 | 0.45 | 0.4 | -0.66 |
116 | 390 | 2h00 (A) | 5 | 246 | 21.00 | 0.17 | 0.22 | 0.297225 | 1.08 |
127 | 306 | 2h00 (B) | 20 | 153 | 35.00 | 0.000000017 | 0.54 | 0.255967 | 0.39 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128986)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G21070 | protein FIONA1 |
Babesia bovis | BBOV_III009280 | conserved hypothetical protein |
Brugia malayi | Bm1_44865 | Hypothetical UPF0049 protein ZK1128.2 in chromosome III |
Caenorhabditis elegans | CELE_ZK1128.2 | Protein METT-10, isoform A |
Cryptosporidium hominis | Chro.60237 | hypothetical protein |
Cryptosporidium parvum | cgd6_2010 | YbiN-like RNA methylase (NPPY variety; HemK family) |
Dictyostelium discoideum | DDB_G0275203 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7544 | CG7544 gene product from transcript CG7544-RB |
Escherichia coli | b0807 | 23S rRNA m(6)A1618 methyltransferase, SAM-dependent |
Echinococcus granulosus | EgrG_001067900 | methyltransferase protein 16 |
Echinococcus multilocularis | EmuJ_001067900 | methyltransferase protein 16 |
Homo sapiens | ENSG00000127804 | methyltransferase like 16 |
Loa Loa (eye worm) | LOAG_01952 | hypothetical protein |
Mus musculus | 67493 | methyltransferase like 16 |
Neospora caninum | NCLIV_032700 | hypothetical protein |
Oryza sativa | 4328120 | Os02g0121200 |
Plasmodium berghei | PBANKA_1030800 | methyltransferase, putative |
Plasmodium falciparum | PF3D7_1411700 | methyltransferase, putative |
Plasmodium knowlesi | PKNH_1346600 | methyltransferase, putative |
Plasmodium vivax | PVX_085870 | hypothetical protein, conserved |
Plasmodium yoelii | PY00160 | putative SAM-dependent methyltransferase |
Schistosoma japonicum | Sjp_0029750 | ko:K06970 METT10D; methyltransferase 10 domain containing, putative |
Schistosoma mansoni | Smp_129140.1 | hypothetical protein |
Schistosoma mansoni | Smp_129140.2 | hypothetical protein |
Schmidtea mediterranea | mk4.000902.06 | |
Schmidtea mediterranea | mk4.044021.00 | Methyltransferase-like protein 16 homolog |
Toxoplasma gondii | TGME49_232750 | 23S rRNA (adenine(1618)-N(6))-methyltransferase, putative |
Theileria parva | TP04_0837 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b0807 | Escherichia coli | non-essential | goodall |
PBANKA_1030800 | Plasmodium berghei | Slow | plasmo |
TGME49_232750 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.