Detailed view for PVX_091825

Basic information

TDR Targets ID: 269110
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 6.7254 | Length (AA): 439 | MW (Da): 48328 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14555   UBA-like domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
69 112 2dal (A) 19 62 27.00 0.00000000066 0.97 0.61 -1.52
165 309 1se1 (A) 103 543 15.00 0 0.88 0.45 0.2
196 315 1ep7 (A) 4 110 13.00 0 0.72 0.41 -0.9
33 113 1wj7 (A) 10 87 21.00 0.013 1 0.48321 -0.27
43 95 5cg9 (A) 121 175 30.00 0.5 0.34 0.456729 -0.39
59 108 2l2d (A) 21 70 18.00 0.82 0.49 0.502595 -1.68
65 129 3bq3 (A) 14 86 22.00 0.054 1 0.608764 -1.49
188 335 2dlx (A) 14 153 31.00 0 0.99 0.61413 0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 24 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_129659)

Species Accession Gene Product
Arabidopsis thaliana AT1G14570   UBX domain-containing protein
Brugia malayi Bm1_13630   UBX domain containing protein
Candida albicans CaO19.11908   possible proteasome function
Candida albicans CaO19.4430   possible proteasome function
Cryptosporidium hominis Chro.30459   AI196514 protein
Cryptosporidium parvum cgd3_4080   conserved protein with UAS domain, possible ubiquitin protein
Dictyostelium discoideum DDB_G0270358   UAS domain-containing protein
Drosophila melanogaster Dmel_CG8892   CG8892 gene product from transcript CG8892-RC
Echinococcus granulosus EgrG_000448400   UBX
Echinococcus multilocularis EmuJ_000448400   UBX
Homo sapiens 26043   UBX domain protein 7
Loa Loa (eye worm) LOAG_07793   UBX domain-containing protein
Mus musculus ENSMUSG00000053774   UBX domain protein 7
Neospora caninum NCLIV_064570   GD22670, related
Oryza sativa 4337356   Os04g0670800
Onchocerca volvulus OVOC2110  
Plasmodium berghei PBANKA_0924100   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1124200   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0922000   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_091825   hypothetical protein, conserved
Saccharomyces cerevisiae YDR330W   Ubx5p
Schistosoma japonicum Sjp_0213410   UBX domain-containing protein 2, putative
Schistosoma mansoni Smp_017110   hypothetical protein
Schistosoma mansoni Smp_131520   hypothetical protein
Schmidtea mediterranea mk4.019525.00  
Schmidtea mediterranea mk4.000413.06  
Toxoplasma gondii TGME49_300150   hypothetical protein

Essentiality

PVX_091825 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_300150 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_091825 (Plasmodium vivax), hypothetical protein, conserved
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