Detailed view for PVX_089165

Basic information

TDR Targets ID: 269243
Plasmodium vivax, dicarboxylate/tricarboxylate carrier, putative
Source Database / ID:  PlasmoDB 

pI: 9.9242 | Length (AA): 318 | MW (Da): 35214 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005488   binding  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 310 1okc (A) 3 293 20.00 0 0.18 1.11 -0.57
181 249 2bju (A) 34 104 38.00 0.67 0.12 0.223781 1.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_127710)

Species Accession Gene Product
Arabidopsis thaliana AT5G19760   mitochondrial substrate carrier family protein
Arabidopsis thaliana AT2G22500   mitochondrial dicarboxylate carrier 1
Babesia bovis BBOV_III005160   mitochondrial carrier protein family protein
Brugia malayi Bm1_07690   mitochondrial 2-oxoglutarate/malate carrier protein, putative
Caenorhabditis elegans CELE_B0432.4   Protein MISC-1
Cryptosporidium hominis Chro.10071   oxoglutarate/malate translocator protein
Cryptosporidium parvum cgd1_600   oxoglutarate/malate translocator protein
Dictyostelium discoideum DDB_G0284225   mitochondrial 2-oxoglutarate/malate carrier protein
Drosophila melanogaster Dmel_CG1907   CG1907 gene product from transcript CG1907-RA
Drosophila melanogaster Dmel_CG18418   CG18418 gene product from transcript CG18418-RA
Drosophila melanogaster Dmel_CG7514   CG7514 gene product from transcript CG7514-RA
Echinococcus granulosus EgrG_000420300   mitochondrial 2 oxoglutarate:malate carrier
Echinococcus multilocularis EmuJ_000420300   mitochondrial 2 oxoglutarate:malate carrier
Homo sapiens ENSG00000108528   solute carrier family 25 (mitochondrial carrier
Leishmania braziliensis LbrM.18.1350   hypothetical protein, conserved
Leishmania braziliensis LbrM.18.1360   hypothetical protein, conserved
Leishmania donovani LdBPK_181280.1   mitochondrial carrier protein, putative
Leishmania donovani LdBPK_181270.1   mitochondrial carrier protein, putative
Leishmania infantum LinJ.18.1680   hypothetical protein, conserved
Leishmania infantum LinJ.18.1280   hypothetical protein, conserved
Leishmania major LmjF.18.1290   hypothetical protein, conserved
Leishmania major LmjF.18.1275   hypothetical protein, conserved
Leishmania major LmjF.18.1265   hypothetical protein, conserved
Leishmania major LmjF.18.1285   hypothetical protein, conserved
Leishmania major LmjF.18.1260   hypothetical protein, conserved
Leishmania major LmjF.18.1280   hypothetical protein, conserved
Leishmania major LmjF.18.1270   hypothetical protein, conserved
Leishmania major LmjF.18.1300   hypothetical protein, conserved
Leishmania mexicana LmxM.18.1300   hypothetical protein, conserved
Leishmania mexicana LmxM.18.1290   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_06488   2-oxoglutarate/malate carrier protein
Mus musculus ENSMUSG00000014606   solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Neospora caninum NCLIV_033680   Solute carrier family 25 (Mitochondrial carrier, dicarboxylate transporter), member 10, related
Oryza sativa 4338082   Os05g0208000
Oryza sativa 9269120   Os11g0437300
Oryza sativa 4350398   Os11g0432400
Oryza sativa 4347309   Os09g0465400
Plasmodium berghei PBANKA_0706700   dicarboxylate/tricarboxylate carrier, putative
Plasmodium falciparum PF3D7_0823900   dicarboxylate/tricarboxylate carrier
Plasmodium knowlesi PKNH_1317900   dicarboxylate/tricarboxylate carrier, putative
Plasmodium vivax PVX_089165   dicarboxylate/tricarboxylate carrier, putative
Plasmodium yoelii PY02084   putative oxoglutarate/malate translocator protein
Schistosoma japonicum Sjp_0056780   Mitochondrial 2-oxoglutarate/malate carrier protein, putative
Schistosoma mansoni Smp_004080   mitochondrial 2-oxoglutarate/malate carrier protein
Schmidtea mediterranea mk4.005694.00   Mitochondrial 2-oxoglutarate/malate carrier protein
Schmidtea mediterranea mk4.000701.00   Mitochondrial 2-oxoglutarate/malate carrier protein
Schmidtea mediterranea mk4.005694.02   Mitochondrial 2-oxoglutarate/malate carrier protein
Schmidtea mediterranea mk4.005076.00   Mitochondrial 2-oxoglutarate/malate carrier protein
Schmidtea mediterranea mk4.005457.00   Mitochondrial 2-oxoglutarate/malate carrier protein
Trypanosoma brucei gambiense Tbg972.10.15490   mitochondrial carrier protein, putative,mitochondrial 2-oxoglutarate/malate carrier protein, putative
Trypanosoma brucei Tb927.10.12840   mitochondrial carrier protein
Trypanosoma congolense TcIL3000_10_10930   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.503939.20   mitochondrial carrier protein
Trypanosoma cruzi TcCLB.509805.190   mitochondrial carrier protein
Toxoplasma gondii TGME49_274060   2-oxoglutarate/malate translocase OMT
Theileria parva TP02_0450   oxoglutarate / malate translocator, putative

Essentiality

PVX_089165 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.12840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.12840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.12840 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.12840 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_274060 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_089165 (Plasmodium vivax), dicarboxylate/tricarboxylate carrier, putative
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