Detailed view for PVX_089570

Basic information

TDR Targets ID: 269286
Plasmodium vivax, meiotic recombination protein DMC1, putative
Source Database / ID:  PlasmoDB 

pI: 6.8757 | Length (AA): 347 | MW (Da): 37718 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08423   Rad51

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005622   intracellular  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0003677   DNA binding  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0008094   DNA-dependent ATPase activity  
GO:0007131   meiotic recombination  
GO:0006281   DNA repair  
GO:0006259   DNA metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 347 1tf7 (A) 144 481 17.00 0 1 0.8 0.62
29 344 1szp (A) 80 394 51.00 0 1 1.52 -0.78
106 347 1n0w (A) 98 339 59.00 0 1 1.35 -1.24
28 345 3lda (A) 79 395 51.00 0.00004 1 1.48113 -0.7
93 345 4hyy (A) 84 338 57.00 0 1 1.42071 -0.95
106 347 1n0w (A) 98 339 59.00 0 1 1.33501 -1.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_126834)

Species Accession Gene Product
Arabidopsis thaliana AT5G20850   DNA repair protein RAD51-like 1
Arabidopsis thaliana AT3G22880   meiotic recombination protein DMC1-like protein
Babesia bovis BBOV_II003540   Rad51 protein, putative
Brugia malayi Bm1_44785   Meiotic recombination protein DMC1/LIM15 homolog, putative
Brugia malayi Bm1_28125   DNA repair protein RAD51 homolog 1
Candida albicans CaO19.3760   similar to S. cerevisiae DMC1p (YER179W) meiosis-specific, single-stranded DNA binding protein
Candida albicans CaO19.11244   similar to S. cerevisiae DMC1p (YER179W) meiosis-specific, single-stranded DNA binding protein
Candida albicans CaO19.11236   similar to S. cerevisiae protein involved in processing ds breaks, synaptonemal complex formation, meiotic gene conversion and r
Candida albicans CaO19.3752   similar to S. cerevisiae protein involved in processing ds breaks, synaptonemal complex formation, meiotic gene conversion and r
Caenorhabditis elegans CELE_Y43C5A.6   Protein RAD-51, isoform B
Cryptosporidium hominis Chro.50352   Rad51
Cryptosporidium hominis Chro.70199   meiotic recombination protein DMC1-like protein
Cryptosporidium parvum cgd7_1690   meiotic recombination protein DMC1-like protein
Cryptosporidium parvum cgd5_410   Rad51
Dictyostelium discoideum DDB_G0273611   hypothetical protein
Dictyostelium discoideum DDB_G0273139   hypothetical protein
Drosophila melanogaster Dmel_CG7948   spindle A
Echinococcus granulosus EgrG_000768100   dna repair protein rad51 1
Entamoeba histolytica EHI_031220   DNA repair protein RAD51, putative
Entamoeba histolytica EHI_050430   Meiotic recombination protein DMC1, putative
Echinococcus multilocularis EmuJ_000768100   dna repair protein rad51 1
Giardia lamblia GL50803_13346   Dmc1b
Giardia lamblia GL50803_13104   DNA repair protein RAD51
Homo sapiens ENSG00000051180   RAD51 recombinase
Homo sapiens ENSG00000100206   DNA meiotic recombinase 1
Leishmania braziliensis LbrM.28.0570   RAD51 protein, putative
Leishmania braziliensis LbrM.34.4850   RAD51/dmc1 protein
Leishmania donovani LdBPK_354950.1   meiotic recombination protein DMC1, putative
Leishmania donovani LdBPK_280580.1   DNA repair protein RAD51, putative
Leishmania infantum LinJ.28.0580   RAD51 protein, putative
Leishmania infantum LinJ.35.4950   RAD51/dmc1 protein
Leishmania major LmjF.35.4890   RAD51/dmc1 protein
Leishmania major LmjF.28.0550   RAD51 protein, putative
Leishmania mexicana LmxM.28.0550   RAD51 protein, putative
Leishmania mexicana LmxM.34.4890   RAD51/dmc1 protein
Loa Loa (eye worm) LOAG_11057   rad51
Loa Loa (eye worm) LOAG_12599   meiotic recombination protein DMC1/LIM15
Mus musculus 19361   RAD51 homolog
Mus musculus ENSMUSG00000022429   DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
Neospora caninum NCLIV_059840   meiotic recombination protein DMC1-like protein, putative
Neospora caninum NCLIV_034540   DNA repair protein, putative
Oryza sativa 4352257   Os12g0497300
Oryza sativa 4349763   Os11g0146800
Oryza sativa 4350923   Os11g0615800
Oryza sativa 4351482   Os12g0143800
Onchocerca volvulus OVOC8548   Meiotic recombination protein DMC1\/LIM15 homolog
Plasmodium berghei PBANKA_0714000   meiotic recombination protein DMC1
Plasmodium berghei PBANKA_0939500   DNA repair protein RAD51
Plasmodium falciparum PF3D7_0816800   meiotic recombination protein DMC1, putative
Plasmodium falciparum PF3D7_1107400   DNA repair protein RAD51
Plasmodium knowlesi PKNH_0905000   DNA repair protein RAD51, putative
Plasmodium knowlesi PKNH_0503600   meiotic recombination protein DMC1, putative
Plasmodium vivax PVX_089570   meiotic recombination protein DMC1, putative
Plasmodium vivax PVX_091045   DNA repair protein RAD51, putative
Plasmodium yoelii PY05593   DNA repair protein rhp51
Plasmodium yoelii PY03786   Rad51 homolog
Saccharomyces cerevisiae YER095W   recombinase RAD51
Saccharomyces cerevisiae YER179W   recombinase DMC1
Schistosoma japonicum Sjp_0000050   ko:K04482 DNA repair protein Rad51, putative
Schistosoma mansoni Smp_124230   DNA repair protein RAD51
Schmidtea mediterranea mk4.024315.01   DNA repair protein RAD51 homolog 1
Schmidtea mediterranea mk4.015647.00   DNA repair protein RAD51 homolog 1
Trypanosoma brucei gambiense Tbg972.9.5490   RAD51/dmc1 protein, putative
Trypanosoma brucei gambiense Tbg972.11.9360   RAD51 protein, putative
Trypanosoma brucei Tb927.9.9620   meiotic recombination protein DMC1, putative
Trypanosoma brucei Tb927.11.8190   DNA repair protein RAD51
Trypanosoma congolense TcIL3000.11.8740   DNA repair protein RAD51, putative
Trypanosoma cruzi TcCLB.508817.50   DNA repair protein RAD51, putative
Trypanosoma cruzi TcCLB.506885.310   meiotic recombination protein DMC1, putative
Trypanosoma cruzi TcCLB.503801.30   DNA repair protein RAD51, putative
Trypanosoma cruzi TcCLB.510729.110   meiotic recombination protein DMC1, putative
Toxoplasma gondii TGME49_216400   meiotic recombination protein DMC1 family protein
Toxoplasma gondii TGME49_272900   DNA repair protein RAD51, putative
Theileria parva TP04_0230   DNA repair protein rad51, putative
Theileria parva TP04_0170   meiotic recombination protein DMC1, putative
Trichomonas vaginalis TVAG_155030   meiosis-specific recA homolog Dmc1
Trichomonas vaginalis TVAG_204070   recombinase Rad51 (recA homolog)

Essentiality

PVX_089570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.0360 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.1210 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1210 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1210 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.1210 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y43C5A.6 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0714000 Plasmodium berghei Dispensable plasmo
TGME49_272900 Toxoplasma gondii Essentiality uncertain sidik
TGME49_216400 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens RAD51 recombinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PVX_089570 (Plasmodium vivax), meiotic recombination protein DMC1, putative
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