pI: 10.0494 |
Length (AA): 89 |
MW (Da): 10741 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 12 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 30 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_129603)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G61220 | LYR family of Fe/S cluster biogenesis protein |
Babesia bovis | BBOV_IV005990 | hypothetical protein |
Brugia malayi | Bm1_43840 | hypothetical protein |
Dictyostelium discoideum | DDB_G0290725 | LYR motif-containing protein 4 |
Drosophila melanogaster | Dmel_CG3717 | CG3717 gene product from transcript CG3717-RA |
Echinococcus granulosus | EgrG_000181700 | LYR motif containing protein 4 |
Echinococcus multilocularis | EmuJ_000181700 | LYR motif containing protein 4 |
Homo sapiens | ENSG00000214113 | LYR motif containing 4 |
Mus musculus | ENSMUSG00000046573 | LYR motif containing 4 |
Neospora caninum | NCLIV_009060 | hypothetical protein, conserved |
Oryza sativa | 4345028 | Os08g0239000 |
Oryza sativa | 4348587 | Os10g0406600 |
Plasmodium berghei | PBANKA_1409500 | protein ISD11, putative |
Plasmodium falciparum | PF3D7_1311000 | protein ISD11 |
Plasmodium knowlesi | PKNH_1411400 | protein ISD11, putative |
Plasmodium vivax | PVX_122380 | protein ISD11, putative |
Saccharomyces cerevisiae | YER048W-A | Isd11p |
Schistosoma japonicum | Sjp_0218740 | expressed protein |
Schistosoma mansoni | Smp_066590 | hypothetical protein |
Toxoplasma gondii | TGME49_254800 | hypothetical protein |
Theileria parva | TP01_0402 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YER048W-A | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1409500 | Plasmodium berghei | Essential | plasmo |
TGME49_254800 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.