Detailed view for PVX_081250

Basic information

TDR Targets ID: 269431
Plasmodium vivax, kinesin-8, putative
Source Database / ID:  PlasmoDB 

pI: 7.0026 | Length (AA): 1488 | MW (Da): 160871 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00225   Kinesin motor domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008017   microtubule binding  
GO:0005524   ATP binding  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
747 1132 1n6m (B) 298 667 33.00 0 1 0.47 -0.09
797 1140 1x88 (A) 18 364 41.00 0 1 0.67 -0.98
797 1170 1sdm (A) 889 1252 36.00 0 1 0.46 -0.61
796 1135 3lre (B) 10 355 54.00 0 1 0.786395 -0.85
797 1179 4frz (A) 889 1245 30.00 0 1 0.404492 0.12
1300 1475 4uos (A) 2 172 22.00 0.97 0.99 0.52418 -1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_127280)

Species Accession Gene Product
Arabidopsis thaliana AT1G18550   ATP binding microtubule motor family protein
Arabidopsis thaliana AT3G49650   P-loop containing nucleoside triphosphate hydrolase-like protein
Babesia bovis BBOV_IV003380   kinesin, putative
Candida albicans CaO19.7353   kinesin motor domain protein
Cryptosporidium hominis Chro.30351   similar to protein FLJ37300
Cryptosporidium parvum cgd3_3090   conserved hypothetical protein
Dictyostelium discoideum DDB_G0293198   kinesin family member 10
Drosophila melanogaster Dmel_CG9913   Kinesin family member 19A ortholog
Drosophila melanogaster Dmel_CG10923   Kinesin-like protein at 67A
Giardia lamblia GL50803_4371   Kinesin-8
Homo sapiens ENSG00000186185   kinesin family member 18B
Homo sapiens ENSG00000121621   kinesin family member 18A
Homo sapiens ENSG00000196169   kinesin family member 19
Mus musculus ENSMUSG00000010021   kinesin family member 19A
Mus musculus 101055939   kinesin-like protein KIF19-like
Mus musculus ENSMUSG00000027115   kinesin family member 18A
Mus musculus ENSMUSG00000051378   kinesin family member 18B
Neospora caninum NCLIV_007650   hypothetical protein
Neospora caninum NCLIV_065120   kinesin motor domain-containing protein, putative
Oryza sativa 4334272   Os03g0773600
Oryza sativa 4324211   Os01g0605500
Plasmodium berghei PBANKA_0202700   kinesin-8, putative
Plasmodium berghei PBANKA_0805900   kinesin-8, putative
Plasmodium falciparum PF3D7_0319400   kinesin-8, putative
Plasmodium falciparum PF3D7_0111000   kinesin-8, putative
Plasmodium knowlesi PKNH_0202500   kinesin-8, putative
Plasmodium knowlesi PKNH_0821800   kinesin-8, putative
Plasmodium vivax PVX_081250   kinesin-8, putative
Plasmodium vivax PVX_095265   kinesin-8, putative
Plasmodium yoelii PY00972   kinesin-related protein
Plasmodium yoelii PY02372   kinesin-like protein-related
Saccharomyces cerevisiae YGL216W   tubulin-dependent ATPase KIP3
Schmidtea mediterranea mk4.008703.00  
Toxoplasma gondii TGME49_253110   kinesin motor domain-containing protein
Toxoplasma gondii TGME49_249020   kinesin motor domain-containing protein
Theileria parva TP01_1097   kinesin, putative
Trichomonas vaginalis TVAG_447880   conserved hypothetical protein
Trichomonas vaginalis TVAG_395330   kinesin eg-5, putative

Essentiality

PVX_081250 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0202700 Plasmodium berghei Dispensable plasmo
PBANKA_0805900 Plasmodium berghei Dispensable plasmo
TGME49_253110 Toxoplasma gondii Probably non-essential sidik
TGME49_249020 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_081250 (Plasmodium vivax), kinesin-8, putative
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