pI: 7.2859 |
Length (AA): 548 |
MW (Da): 62571 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
136 | 163 | 1zr7 (A) | 12 | 39 | 18.00 | 0.000017 | 0.19 | 0.38 | -1.33 |
9 | 51 | 4pjo (L) | 2 | 45 | 23.00 | 0.0072 | 0.42 | 0.366167 | -0.54 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_130756)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G49590 | zinc-finger and ocre domain-containing protein 1 |
Babesia bovis | BBOV_III008510 | hypothetical protein |
Brugia malayi | Bm1_20195 | U1 zinc finger family protein |
Caenorhabditis elegans | CELE_F56G4.4 | Protein F56G4.4 |
Cryptosporidium hominis | Chro.30174 | hypothetical protein |
Cryptosporidium parvum | cgd3_1440 | U1 small nuclear ribonucleoprotein c like finger |
Dictyostelium discoideum | DDB_G0286361 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4291 | CG4291 gene product from transcript CG4291-RB |
Echinococcus granulosus | EgrG_001195200 | ww domain binding protein 4 |
Echinococcus multilocularis | EmuJ_001195200 | ww domain binding protein 4 |
Homo sapiens | ENSG00000120688 | WW domain binding protein 4 |
Loa Loa (eye worm) | LOAG_05542 | U1 zinc finger family protein |
Mus musculus | ENSMUSG00000022023 | WW domain binding protein 4 |
Neospora caninum | NCLIV_005380 | ww domain U1 zinc finger domain-containing protein, putative |
Plasmodium berghei | PBANKA_1039500 | zinc finger protein, putative |
Plasmodium falciparum | PF3D7_1402400 | zinc finger protein, putative |
Plasmodium knowlesi | PKNH_1355700 | zinc finger protein, putative |
Plasmodium vivax | PVX_086310 | hypothetical protein, conserved |
Plasmodium yoelii | PY00121 | hypothetical protein |
Schistosoma japonicum | Sjp_0005310 | expressed protein |
Schistosoma mansoni | Smp_133940 | hypothetical protein |
Schmidtea mediterranea | mk4.000620.09 | |
Toxoplasma gondii | TGME49_221980 | U1 zinc finger protein |
Theileria parva | TP04_0754 | hypothetical protein |
Theileria parva | TP04_0753 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F56G4.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F56G4.4 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1039500 | Plasmodium berghei | Essential | plasmo |
TGME49_221980 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.