Detailed view for PVX_085580

Basic information

TDR Targets ID: 269866
Plasmodium vivax, rap guanine nucleotide exchange factor, putative
Source Database / ID:  PlasmoDB 

pI: 7.2359 | Length (AA): 3335 | MW (Da): 383979 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1786 2071 1cx4 (A) 133 408 18.00 0 1 0.29 -0.54
1918 2060 1q3e (A) 496 635 16.00 0.0000000021 0.99 0.35 -1.26
2930 3202 1ne6 (A) 115 372 25.00 0 1 0.45 -1
3066 3197 1pf0 (A) 219 344 25.00 0.000000000069 0.99 0.41 -1.41
2 174 4uos (A) 2 175 12.00 0.26 0.05 0.268574 -1.5
721 901 4tql (A) 80 239 30.00 0.00066 0.59 0.391273 -1.37
723 812 3u59 (A) 5 94 30.00 0.52 0.06 0.555987 -2.92
1757 2386 4rz7 (A) 3 610 16.00 0 1 0.210706 1.03
1928 2058 4ofg (A) 407 534 25.00 0.00011 1 0.43108 -1.17
2326 2470 3fhi (B) 115 229 34.00 0.032 1 0.0994783 0.55
2693 2830 3b81 (A) 70 197 38.00 0.34 0.39 0.0123793 1.29
2921 3208 2qvs (B) 97 388 18.00 0.000000019 0.99 0.207157 0.63
2926 3203 2qvs (B) 107 383 24.00 0.0000026 1 0.242358 0.72
3076 3189 4d7s (A) 295 404 31.00 0.19 0.5 0.387183 -0.32
3095 3215 3gyd (A) 40 159 18.00 0.0041 0.22 0.158082 0.25
3095 3186 3fhi (B) 148 233 28.00 0.0076 0.51 0.244386 -0.01
3227 3310 3dv8 (A) 136 219 10.00 0.014 0.01 0.220887 -1.43
3253 3308 3e97 (A) 168 223 4.00 0.27 0 0.147492 -1.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_141204)

Species Accession Gene Product
Babesia bovis BBOV_II005560   cyclic nucleotide-binding domain containing protein
Cryptosporidium hominis Chro.80459   hypothetical protein
Cryptosporidium hominis Chro.80460   reticulocyte-binding protein 2 A
Cryptosporidium parvum cgd8_4000   large protein with 3x cNMP binding domain
Neospora caninum NCLIV_061400   GI16562, related
Plasmodium berghei PBANKA_1025300   rap guanine nucleotide exchange factor, putative
Plasmodium knowlesi PKNH_1340600   rap guanine nucleotide exchange factor, putative
Plasmodium vivax PVX_085580   rap guanine nucleotide exchange factor, putative
Plasmodium yoelii PY05448   reticulocyte-binding protein 2 homolog A, putative
Toxoplasma gondii TGME49_325000   hypothetical protein
Toxoplasma gondii TGME49_219070   cyclic nucleotide-binding domain-containing protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_085580 (Plasmodium vivax), rap guanine nucleotide exchange factor, putative
Title for this comment
Comment