Detailed view for PF3D7_1439500

Basic information

TDR Targets ID: 2705
Plasmodium falciparum, oocyst rupture protein 2, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.1663 | Length (AA): 1074 | MW (Da): 123019 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00125   Core histone H2A/H2B/H3/H4

Gene Ontology

Mouse over links to read term descriptions.
GO:0046982   protein heterodimerization activity  
GO:0016602   CCAAT-binding factor complex  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005622   intracellular  
GO:0000786   nucleosome  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0043565   sequence-specific DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 115 1n1j (B) 43 120 60.00 0.000000000014 1 0.8 -0.85
2 31 2en8 (A) 10 39 13.00 0.46 0.02 0.172733 -0.49
2 32 2em4 (A) 10 40 10.00 0.32 0.01 0.0746641 0.19
292 400 3ult (A) 6 114 33.00 0.022 0.18 0.43769 -1.13
797 1016 4fmz (A) 105 330 26.00 0.094 1 0.381042 0.19
3 114 4g92 (C) 56 163 48.00 0 0.92 0.666571 -0.36
31 114 4csr (B) 39 119 58.00 0 1 0.725378 -0.13
34 99 1jfi (A) 11 73 38.00 0.67 0.31 0.34124 -0.08
293 399 3ult (A) 6 114 33.00 0.012 0.14 0.428894 -0.91
302 412 3ik2 (A) 388 496 33.00 0.18 0.16 0.203635 0.3
785 1011 4fmz (A) 98 330 26.00 0.05 1 0.384148 0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, merozoite, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, late ring, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, Female Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128092)

Species Accession Gene Product
Arabidopsis thaliana AT1G56170   nuclear transcription factor Y subunit C-2
Arabidopsis thaliana AT3G48590   nuclear transcription factor Y subunit C-1
Arabidopsis thaliana AT5G63470   nuclear transcription factor Y subunit C-4
Babesia bovis BBOV_I001540   histone-like transcription factor (CBF/NF-Y) and archaeal histone domain containing protein
Candida albicans CaO19.1973   Component of heterotrimeric CCAAT-binding factor
Candida albicans CaO19.9529   Component of heterotrimeric CCAAT-binding factor
Caenorhabditis elegans CELE_F23F1.1   Protein NFYC-1
Dictyostelium discoideum DDB_G0273479   hypothetical protein
Dictyostelium discoideum DDB_G0268506   hypothetical protein
Dictyostelium discoideum DDB_G0273545   hypothetical protein
Dictyostelium discoideum DDB_G0289971   hypothetical protein
Drosophila melanogaster Dmel_CG3075   Nuclear factor Y-box C
Echinococcus granulosus EgrG_000459300   nuclear transcription factor Y gamma
Echinococcus granulosus EgrG_000459200   nuclear transcription factor Y gamma
Entamoeba histolytica EHI_076830   CBF/NF-Y transcription factor domain protein
Echinococcus multilocularis EmuJ_000459300   nuclear transcription factor Y, gamma
Echinococcus multilocularis EmuJ_000459200   nuclear transcription factor Y gamma
Giardia lamblia GL50803_14553   CCAAT-binding transcription factor subunit C
Homo sapiens ENSG00000066136   nuclear transcription factor Y, gamma
Mus musculus ENSMUSG00000032897   nuclear transcription factor-Y gamma
Oryza sativa 4345928   Os08g0496500
Oryza sativa 4347391   Os09g0480700
Oryza sativa 4328444   Os02g0170500
Oryza sativa 9266204   Os03g0251350
Oryza sativa 4341785   Os06g0667100
Plasmodium berghei PBANKA_1303400   oocyst rupture protein 2
Plasmodium falciparum PF3D7_1439500   oocyst rupture protein 2, putative
Plasmodium knowlesi PKNH_1242800   oocyst rupture protein 2, putative
Plasmodium vivax PVX_118515   histone, putative
Plasmodium yoelii PY00826   hypothetical protein
Saccharomyces cerevisiae YOR358W   Hap5p
Schistosoma japonicum Sjp_0087470   Nuclear transcription factor Y subunit C-2, putative
Schistosoma japonicum Sjp_0303100   ko:K08066 nuclear transcription factor Y, gamma, putative
Schistosoma mansoni Smp_176340   CCAAT-binding transcription factor
Schmidtea mediterranea mk4.000072.03   CCAAT-binding transcription factor, putative
Theileria parva TP01_0584   hypothetical protein

Essentiality

PF3D7_1439500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F23F1.1 Caenorhabditis elegans larval arrest wormbase
PBANKA_1303400 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1439500 (Plasmodium falciparum), oocyst rupture protein 2, putative
Title for this comment
Comment