Detailed view for LmjF.36.2590

Basic information

TDR Targets ID: 27203
Leishmania major, membrane-bound acid phosphatase 2, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.3702 | Length (AA): 571 | MW (Da): 62622 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00328   Histidine phosphatase superfamily (branch 2)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003993   acid phosphatase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 412 1rpa () 1 340 23.00 0 1 0.81 -0.21
44 412 1rpa () 2 340 24.00 0 1 0.86 -0.43
41 415 4job (A) 46 419 24.00 0 1 0.721843 0.05
43 216 3zhc (A) 6 165 29.00 0.58 0.6 0.309329 1.38
43 415 2wnh (A) 14 403 17.00 0 1 0.79664 -0.16
44 355 3it3 (A) 7 303 26.00 0.00000098 0.98 0.75301 0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127341)

Species Accession Gene Product
Brugia malayi Bm1_23365   Histidine acid phosphatase family protein
Caenorhabditis elegans CELE_T13B5.3   Protein PHO-14
Caenorhabditis elegans CELE_B0361.7   Protein PHO-5
Drosophila melanogaster Dmel_CG7899   Acid phosphatase 1
Echinococcus granulosus EgrG_000985400   lysosomal acid phosphatase
Echinococcus granulosus EgrG_000814600   lysosomal acid phosphatase
Entamoeba histolytica EHI_039860   histidine acid phosphatase family protein
Entamoeba histolytica EHI_146950   histidine acid phosphatase family protein
Echinococcus multilocularis EmuJ_000985400   lysosomal acid phosphatase
Echinococcus multilocularis EmuJ_000814600   lysosomal acid phosphatase
Echinococcus multilocularis EmuJ_000985000   lysosomal acid phosphatase
Echinococcus multilocularis EmuJ_000985200   lysosomal acid phosphatase
Giardia lamblia GL50803_7556   Lysosomal acid phosphatase precursor
Homo sapiens ENSG00000014257   acid phosphatase, prostate
Homo sapiens ENSG00000134575   acid phosphatase 2, lysosomal
Leishmania braziliensis LbrM.35.2800   membrane-bound acid phosphatase 2, putative
Leishmania braziliensis LbrM.23.1290   membrane-bound acid phosphatase 2
Leishmania donovani LdBPK_231430.1   membrane-bound acid phosphatase 2
Leishmania donovani LdBPK_362720.1   membrane-bound acid phosphatase 2, putative
Leishmania infantum LinJ.36.2720   membrane-bound acid phosphatase 2, putative
Leishmania infantum LinJ.23.1430   membrane-bound acid phosphatase 2
Leishmania major LmjF.36.2590   membrane-bound acid phosphatase 2, putative
Leishmania major LmjF.23.1170   membrane-bound acid phosphatase 2
Leishmania mexicana LmxM.23.1170   membrane-bound acid phosphatase 2
Leishmania mexicana LmxM.36.2590   membrane-bound acid phosphatase 2, putative
Loa Loa (eye worm) LOAG_08653   hypothetical protein
Loa Loa (eye worm) LOAG_06638   hypothetical protein
Mus musculus ENSMUSG00000032561   acid phosphatase, prostate
Mus musculus ENSMUSG00000002103   acid phosphatase 2, lysosomal
Onchocerca volvulus OVOC12067  
Schistosoma japonicum Sjp_0001830   Lysosomal acid phosphatase precursor, putative
Schistosoma japonicum Sjp_0301810   ko:K01078 acid phosphatase [EC3.1.3.2], putative
Schistosoma japonicum Sjp_0202310   Testicular acid phosphatase homolog precursor, putative
Schistosoma mansoni Smp_123670   acid phosphatase-related
Schistosoma mansoni Smp_016640   prostatic acid phosphatase
Schmidtea mediterranea mk4.001619.03  
Schmidtea mediterranea mk4.004795.01   Acid phosphatase-related
Schmidtea mediterranea mk4.007965.00   Prostatic acid phosphatase, putative
Schmidtea mediterranea mk4.001619.08  
Trypanosoma brucei gambiense Tbg972.11.14650   membrane-bound acid phosphatase 1 precursor, putative
Trypanosoma brucei gambiense Tbg972.10.8740   membrane-bound acid phosphatase 2, putative
Trypanosoma brucei Tb927.11.13130   membrane-bound acid phosphatase 1 precursor
Trypanosoma brucei Tb927.10.7140   membrane-bound acid phosphatase 2
Trypanosoma congolense TcIL3000.11.13530   membrane-bound acid phosphatase 2
Trypanosoma cruzi TcCLB.510105.250   membrane-bound acid phosphatase 2, putative
Trypanosoma cruzi TcCLB.509717.100   membrane-bound acid phosphatase 2, putative
Trypanosoma cruzi TcCLB.508479.250   membrane-bound acid phosphatase 2, putative
Trichomonas vaginalis TVAG_319780   Lysophosphatidic acid phosphatase type 6 precursor, putative
Trichomonas vaginalis TVAG_026220   acid phosphatase, putative
Trichomonas vaginalis TVAG_149710   conserved hypothetical protein
Trichomonas vaginalis TVAG_402240   acid phosphatase, putative
Trichomonas vaginalis TVAG_508080   acid phosphatase, putative
Trichomonas vaginalis TVAG_267550   conserved hypothetical protein
Trichomonas vaginalis TVAG_552750   conserved hypothetical protein
Trichomonas vaginalis TVAG_066700   conserved hypothetical protein
Trichomonas vaginalis TVAG_169070   acid phosphatase, putative
Trichomonas vaginalis TVAG_552740   conserved hypothetical protein
Trichomonas vaginalis TVAG_218800   conserved hypothetical protein
Trichomonas vaginalis TVAG_526230   conserved hypothetical protein
Trichomonas vaginalis TVAG_125790   conserved hypothetical protein
Trichomonas vaginalis TVAG_259550   prostatic acid phosphatase, putative
Trichomonas vaginalis TVAG_295100   conserved hypothetical protein
Trichomonas vaginalis TVAG_094150   conserved hypothetical protein
Trichomonas vaginalis TVAG_061960   acid phosphatase, putative
Trichomonas vaginalis TVAG_228930   acid phosphatase, putative
Trichomonas vaginalis TVAG_391150   conserved hypothetical protein
Trichomonas vaginalis TVAG_297090   histidine acid phosphatase, putative
Trichomonas vaginalis TVAG_370060   testicular acid phosphatase, putative
Trichomonas vaginalis TVAG_573200   conserved hypothetical protein

Essentiality

LmjF.36.2590 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4701 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4701 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4701 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4701 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.7140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.7140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.7140 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.7140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens acid phosphatase, prostate Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0051 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.2590 (Leishmania major), membrane-bound acid phosphatase 2, putative
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