Detailed view for PF3D7_1441200

Basic information

TDR Targets ID: 2722
Plasmodium falciparum, 60S ribosomal protein L1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.5683 | Length (AA): 217 | MW (Da): 24805 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00687   Ribosomal protein L1p/L10e family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  
GO:0006396   RNA processing  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 215 1ad2 () 11 224 24.00 0 1 1.15 0.02
4 215 1dwu (A) 1 211 26.00 0 1 1.41 -0.97
1 216 4reo (A) 11 225 24.00 0 1 1.26159 0.1
4 216 1dwu (A) 1 212 26.00 0 1 1.36317 -0.74
4 215 4lq4 (A) 1 211 25.00 0 1 1.37156 -0.61
7 190 3qoy (A) 28 201 29.00 0.00000012 1 1.08553 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, Sporozoite. PlasmoDB Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127114)

Species Accession Gene Product
Arabidopsis thaliana AT1G08360   60S ribosomal protein L10a-1
Arabidopsis thaliana AT5G22440   60S ribosomal protein L10a-3
Arabidopsis thaliana AT2G27530   60S ribosomal protein L10a-2
Babesia bovis BBOV_III003180   ribosomal protein L1, putative
Brugia malayi Bm1_01805   60S ribosomal protein L10a
Candida albicans CaO19.10969   likely ribosomal protein L1
Candida albicans CaO19.3465   likely ribosomal protein L1
Caenorhabditis elegans CELE_Y71F9AL.13   Protein RPL-1, isoform B
Cryptosporidium hominis Chro.80334   ribosomal protein L1
Cryptosporidium parvum cgd8_2870   60S ribosomal protein L10A
Dictyostelium discoideum DDB_G0276871   S60 ribosomal protein L10a
Drosophila melanogaster Dmel_CG7283   Ribosomal protein L10Ab
Echinococcus granulosus EgrG_000776500   60S ribosomal protein L10a
Entamoeba histolytica EHI_135790   60S ribosomal protein L10a, putative
Entamoeba histolytica EHI_012480   60S ribosomal protein L10a-2, putative
Echinococcus multilocularis EmuJ_000776500   60S ribosomal protein L10a
Giardia lamblia GL50803_1345   Ribosomal protein L10a
Homo sapiens ENSG00000198755   ribosomal protein L10a
Leishmania braziliensis LbrM.35.4000   60S ribosomal protein L10a, putative
Leishmania braziliensis LbrM.18.0700   60S ribosomal protein L10a, putative
Leishmania infantum LinJ.36.3950   60S ribosomal protein L10a, putative
Leishmania infantum LinJ.18.0630   60S ribosomal protein L10a, putative
Leishmania major LmjF.18.0620   60S ribosomal protein L10a, putative
Leishmania major LmjF.36.3760   60S ribosomal protein L10a, putative
Leishmania mexicana LmxM.36.3760   60S ribosomal protein L10a, putative
Leishmania mexicana LmxM.18.0620   60S ribosomal protein L10a, putative
Loa Loa (eye worm) LOAG_12216   60S ribosomal protein L10a
Mus musculus ENSMUSG00000037805   ribosomal protein L10A
Neospora caninum NCLIV_052390   hypothetical protein
Oryza sativa 9268245   Os08g0558000
Oryza sativa 9266191   Os08g0558800
Oryza sativa 4329171   Os02g0321900
Oryza sativa 4325065   Os01g0860300
Plasmodium berghei PBANKA_1305100   60S ribosomal protein L1, putative
Plasmodium falciparum PF3D7_1441200   60S ribosomal protein L1, putative
Plasmodium knowlesi PKNH_1241100   60S ribosomal protein L1, putative
Plasmodium vivax PVX_118430   60S ribosomal protein L10a, putative
Plasmodium yoelii PY05328   L1P family of ribosomal proteins
Saccharomyces cerevisiae YPL220W   ribosomal 60S subunit protein L1A
Saccharomyces cerevisiae YGL135W   ribosomal 60S subunit protein L1B
Schistosoma japonicum Sjp_0217590   ko:K02865 large subunit ribosomal protein L10Ae, putative
Schistosoma mansoni Smp_042090.3   60S ribosomal protein L10a
Schistosoma mansoni Smp_042090.2   60S ribosomal protein L10a
Schmidtea mediterranea mk4.000514.13   60S ribosomal protein L10a
Schmidtea mediterranea mk4.001260.01   60S ribosomal protein L10a
Schmidtea mediterranea mk4.009045.00  
Trypanosoma brucei gambiense Tbg972.11.10900   60S ribosomal protein L10a, putative
Trypanosoma brucei gambiense Tbg972.10.16300   60S ribosomal protein L10a, putative
Trypanosoma brucei Tb927.11.9710   60S ribosomal protein L10a, putative
Trypanosoma brucei Tb927.10.13500   60S ribosomal protein L10a
Trypanosoma congolense TcIL3000.11.10200   60S ribosomal protein L10a, putative
Trypanosoma congolense TcIL3000_0_35380   60S ribosomal protein L10a, putative
Trypanosoma cruzi TcCLB.511277.160   60S ribosomal protein L10a, putative
Trypanosoma cruzi TcCLB.511233.7   60S ribosomal protein L10a, putative
Trypanosoma cruzi TcCLB.506963.10   60S ribosomal protein L10a, putative
Toxoplasma gondii TGME49_215470   ribosomal protein RPL10A
Theileria parva TP04_0125   60S ribosomal protein L1, putative
Trichomonas vaginalis TVAG_276180   60S ribosomal protein L10a, putative
Trichomonas vaginalis TVAG_144550   60S ribosomal protein L10a, putative
Trichomonas vaginalis TVAG_249740   60S ribosomal protein L10a, putative
Trichomonas vaginalis TVAG_107720   60S ribosomal protein L10a, putative
Trichomonas vaginalis TVAG_477470   60S ribosomal protein L10a, putative
Trichomonas vaginalis TVAG_074480   60S ribosomal protein L10a, putative

Essentiality

PF3D7_1441200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13500 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.13500 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.13500 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.13500 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.1470 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.1470 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.1470 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.1470 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y71F9AL.13 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71F9AL.13 Caenorhabditis elegans larval arrest wormbase
CELE_Y71F9AL.13 Caenorhabditis elegans slow growth wormbase
CELE_Y71F9AL.13 Caenorhabditis elegans sterile wormbase
PBANKA_1305100 Plasmodium berghei Essential plasmo
TGME49_215470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1441200 (Plasmodium falciparum), 60S ribosomal protein L1, putative
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