Detailed view for PF3D7_1442600

Basic information

TDR Targets ID: 2735
Plasmodium falciparum, TRAP-like protein
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.5369 | Length (AA): 3543 | MW (Da): 412691 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0008150   biological_process  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 25 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
104 799 3s5m (A) 256 999 24.00 0.077 0.81 0.0967437 1.42
321 543 4tql (A) 17 236 19.00 0.0000082 0.15 0.355541 -1.62
326 513 3na7 (A) 10 187 28.00 0.38 0.41 0.219362 -0.14
435 585 2efr (A) 150 300 19.00 0.087 0.11 0.326219 -1.37
1277 1831 4gf2 (A) 190 740 14.00 0.32 0 0.259247 -0.17
2785 2992 4uos (A) 0 183 40.00 0.00012 1 0.577007 -1.77
2836 3047 4tql (A) 14 238 36.00 0.000029 1 0.499136 -1.58
2862 3080 4f61 (I) 32 243 32.00 0.078 0.02 0.298112 -0.53
3021 3406 4l6y (A) 33 449 15.00 0.41 0.02 0.191547 -0.45
3042 3274 1jad (A) 3 241 23.00 0.11 0.34 0.365363 -1.2
3121 3310 4uos (A) 0 183 30.00 0.0054 0.98 0.573227 -2.06
3202 3446 4hte (A) 305 591 30.00 0.11 0.14 0.0744504 0.5
21 971 3s5k (A) 151 1166 18.00 0.00026 0.75 0.205993 1.2
321 549 4tql (A) 10 238 13.00 0.0029 0.15 0.271831 -1.43
405 525 4ll8 (E) 57 172 18.00 0.4 0.06 0.288854 -1.53
447 697 4etp (A) 335 601 24.00 0.87 0.29 0.194323 0.09
1500 1766 4o87 (A) 30 306 30.00 0.46 0.41 0.152971 0.27
2182 2434 3uau (A) 20 314 30.00 0.024 0.38 0.0729038 0.4
2550 2811 1c1g (A) 24 280 27.00 0.003 0.01 0.241519 -0.83
2839 3034 4tql (A) 14 224 35.00 0.00012 1 0.342344 -1.04
2868 3059 4uos (A) 0 183 33.00 0.00016 0.71 0.565181 -1.87
2949 3173 1jad (A) 3 241 23.00 0.053 0.2 0.314069 -1.14
2956 3148 4uos (A) 0 184 30.00 0.0023 0.98 0.572772 -2.04
3026 3328 3hjl (A) 23 325 18.00 0.7 0.13 0.20573 -0.2
3101 3345 4hte (A) 305 591 30.00 0.1 0.14 0.0765795 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late trophozoite, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_159959)

Species Accession Gene Product
Cryptosporidium hominis Chro.50153   hypothetical protein
Cryptosporidium hominis Chro.50155   hypothetical protein
Cryptosporidium parvum cgd5_2250   hypothetical protein
Plasmodium falciparum PF3D7_1442600   TRAP-like protein
Plasmodium knowlesi PKNH_1239700   TRAP-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1442600 (Plasmodium falciparum), TRAP-like protein
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