pI: 10.7838 |
Length (AA): 163 |
MW (Da): 18425 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
75 | 162 | 1x57 (A) | 8 | 85 | 45.00 | 0.000000000067 | 0.99 | 0.96 | -0.05 |
88 | 150 | 1b0n (A) | 2 | 65 | 17.00 | 0.00000000002 | 0.43 | 0.74 | -1.62 |
75 | 162 | 1x57 (A) | 8 | 85 | 45.00 | 0.00000000028 | 1 | 0.967277 | -0.1 |
82 | 161 | 1x57 (A) | 8 | 87 | 36.00 | 0 | 0.98 | 1.0392 | -1.23 |
85 | 144 | 2wiu (B) | 10 | 69 | 18.00 | 0.00011 | 0.49 | 0.745598 | -1.56 |
88 | 147 | 1y7y (A) | 14 | 73 | 27.00 | 0.000000072 | 0.81 | 0.864598 | -1.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127833)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G42680 | multiprotein bridging factor 1A |
Arabidopsis thaliana | AT3G58680 | multiprotein-bridging factor 1b |
Arabidopsis thaliana | AT3G24500 | multiprotein-bridging factor 1c |
Babesia bovis | BBOV_I000130 | multiprotein bridging factor type 1 |
Brugia malayi | Bm1_39920 | homologous to Bombyx mori multiprotein bridging factor, putative |
Candida albicans | CaO19.10804 | multiprotein bridging factor |
Candida albicans | CaO19.3294 | multiprotein bridging factor |
Caenorhabditis elegans | CELE_H21P03.1 | Protein MBF-1 |
Cryptosporidium hominis | Chro.30426 | multiprotein bridging factor type 1 |
Cryptosporidium parvum | cgd3_3750 | multiprotein bridging factor type 1 like transcriptional co-activator |
Dictyostelium discoideum | DDB_G0273061 | hypothetical protein |
Dictyostelium discoideum | DDB_G0273775 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4143 | multiprotein bridging factor 1 |
Echinococcus granulosus | EgrG_000845500 | endothelial differentiation factor |
Entamoeba histolytica | EHI_093330 | Helix-turn-helix protein, putative |
Echinococcus multilocularis | EmuJ_000845500 | endothelial differentiation factor |
Homo sapiens | ENSG00000107223 | endothelial differentiation-related factor 1 |
Leishmania braziliensis | LbrM.19.0500 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_190180.1 | multiprotein-bridging factor 1, putative |
Leishmania infantum | LinJ.19.0180 | hypothetical protein, conserved |
Leishmania major | LmjF.19.0190 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.19.0190 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05345 | MBF-1 protein |
Mus musculus | ENSMUSG00000015092 | endothelial differentiation-related factor 1 |
Mus musculus | 665181 | predicted gene 11964 |
Neospora caninum | NCLIV_067470 | hypothetical protein |
Oryza sativa | 4345388 | Os08g0366100 |
Oryza sativa | 4341420 | Os06g0592500 |
Plasmodium berghei | PBANKA_0920000 | multiprotein-bridging factor 1, putative |
Plasmodium falciparum | PF3D7_1128200 | multiprotein-bridging factor 1, putative |
Plasmodium knowlesi | PKNH_0926300 | multiprotein-bridging factor 1, putative |
Plasmodium vivax | PVX_092030 | multiprotein bridging factor type 1, putative |
Plasmodium yoelii | PY05916 | multiprotein bridging factor type 1 |
Saccharomyces cerevisiae | YOR298C-A | Mbf1p |
Schistosoma japonicum | Sjp_0038760 | ko:K03627 putative transcription factor, putative |
Schistosoma mansoni | Smp_140680.1 | endothelial differentiation-related factor 1 |
Schistosoma mansoni | Smp_140680.2 | endothelial differentiation-related factor 1 |
Schmidtea mediterranea | mk4.025256.00 | Endothelial differentiation-related factor 1 |
Schmidtea mediterranea | mk4.001374.01 | Endothelial differentiation-related factor 1 |
Schmidtea mediterranea | mk4.012724.00 | Endothelial differentiation-related factor 1 |
Trypanosoma brucei gambiense | Tbg972.10.17980 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.14810 | multiprotein-bridging factor 1, putative |
Trypanosoma congolense | TcIL3000_10_12680 | multiprotein-bridging factor 1, putative |
Trypanosoma cruzi | TcCLB.511289.59 | multiprotein-bridging factor 1, putative |
Trypanosoma cruzi | TcCLB.506211.170 | multiprotein-bridging factor 1, putative |
Toxoplasma gondii | TGME49_278530 | multiprotein bridging factor type 1 family transcriptional co-activator, putative |
Theileria parva | TP03_0858 | multiprotein bridging factor type 1, putative |
Trichomonas vaginalis | TVAG_303670 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14810 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14810 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14810 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14810 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_278530 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Lmaj002687; Recombinant protein: full-length; Source: L major; hypothetical protein, conserved ; |