Detailed view for LmjF.34.1430

Basic information

TDR Targets ID: 27381
Leishmania major, tyrosine phosphatase isoform, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1232 | Length (AA): 576 | MW (Da): 66281 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00782   Dual specificity phosphatase, catalytic domain
PF10409   C2 domain of PTEN tumour-suppressor protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0008138   protein tyrosine/serine/threonine phosphatase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 381 1wch (A) 2173 2477 13.00 0 0.21 0.44 -0.24
198 568 1d5r (A) 14 350 30.00 0 1 0.72 0.14
198 369 1d5r (A) 14 182 44.00 0 1 0.9 -1.25
198 565 1d5r (A) 14 347 33.00 0 1 0.8 -0.06
197 569 3v0d (A) 252 574 31.00 0 1 0.842469 0.03
222 373 2hcm (A) 11 153 17.00 0 0.3 0.474789 -0.86
267 318 2cfv (A) 1188 1250 43.00 0.31 0.07 0.253878 0.88
273 372 2cjz (A) 437 534 28.00 0.42 0.97 0.533211 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_163860)

Species Accession Gene Product
Leishmania braziliensis LbrM.14.1280   tyrosine phosphatase isoform
Leishmania donovani LdBPK_341530.1   tyrosine phosphatase isoform, putative
Leishmania infantum LinJ.34.1530   tyrosine phosphatase isoform, putative
Leishmania major LmjF.34.1430   tyrosine phosphatase isoform, putative
Leishmania mexicana LmxM.33.1430   tyrosine phosphatase isoform, putative
Trypanosoma cruzi TcCLB.510099.90   tyrosine phosphatase isoform, putative
Trypanosoma cruzi TcCLB.506637.100   tyrosine phosphatase isoform, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.34.1430 (Leishmania major), tyrosine phosphatase isoform, putative
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