pI: 8.8197 |
Length (AA): 1093 |
MW (Da): 119331 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
202 | 563 | 4ylr (A) | 43 | 463 | 38.00 | 0 | 1 | 0.557099 | 0.18 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128542)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG16716 | CG16716 gene product from transcript CG16716-RC |
Drosophila melanogaster | Dmel_CG5987 | CG5987 gene product from transcript CG5987-RA |
Echinococcus granulosus | EgrG_001125100 | tubulin polyglutamylase TTLL7 |
Echinococcus granulosus | EgrG_001045700 | tubulin polyglutamylase TTLL13 |
Echinococcus multilocularis | EmuJ_001045700 | tubulin polyglutamylase TTLL13 |
Echinococcus multilocularis | EmuJ_001125100 | tubulin polyglutamylase TTLL7 |
Giardia lamblia | GL50803_95661 | Tubulin tyrosine ligase |
Homo sapiens | ENSG00000170703 | tubulin tyrosine ligase-like family, member 6 |
Homo sapiens | 79739 | tubulin tyrosine ligase-like family, member 7 |
Leishmania braziliensis | LbrM.11.0080 | tubulin-tyrsoine ligase-like protein |
Leishmania donovani | LdBPK_110400.1 | tubulin-tyrsoine ligase-like protein |
Leishmania infantum | LinJ.11.0400 | tubulin-tyrsoine ligase-like protein |
Leishmania major | LmjF.11.0400 | tubulin-tyrsoine ligase-like protein |
Leishmania mexicana | LmxM.11.0400 | tubulin-tyrsoine ligase-like protein |
Mus musculus | ENSMUSG00000036745 | tubulin tyrosine ligase-like family, member 7 |
Mus musculus | ENSMUSG00000038756 | tubulin tyrosine ligase-like family, member 6 |
Mus musculus | ENSMUSG00000045467 | tubulin tyrosine ligase-like family, member 13 |
Neospora caninum | NCLIV_031170 | tubulin-tyrosine ligase family domain-containing protein, putative |
Plasmodium berghei | PBANKA_1208000 | tubulin--tyrosine ligase, putative |
Plasmodium falciparum | PF3D7_1009700 | tubulin--tyrosine ligase, putative |
Plasmodium knowlesi | PKNH_0809400 | tubulin--tyrosine ligase, putative |
Plasmodium vivax | PVX_094700 | tubulin--tyrosine ligase, putative |
Plasmodium yoelii | PY02532 | hypothetical protein |
Schistosoma japonicum | Sjp_0060700 | ko:K06047 tubulin tyrosine ligase-like family member 6 [EC:6.3.2.25], putative |
Schistosoma mansoni | Smp_074830 | tubulin tyrosine ligase |
Schmidtea mediterranea | mk4.000423.02 | Tubulin tyrosine ligase-related |
Schmidtea mediterranea | mk4.000864.03 | Tubulin polyglutamylase TTLL7 |
Trypanosoma brucei gambiense | Tbg972.11.7740 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma brucei | Tb11.v5.0901 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma brucei | Tb927.11.6810 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma congolense | TcIL3000_0_21510 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma congolense | TcIL3000.11.7370 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma cruzi | TcCLB.511169.29 | tubulin-tyrsoine ligase-like protein, putative |
Trypanosoma cruzi | TcCLB.506775.30 | tubulin-tyrosine ligase-like protein, putative |
Trypanosoma cruzi | TcCLB.508797.10 | tubulin-tyrosine ligase-like protein, putative |
Toxoplasma gondii | TGME49_230670 | Tubulin-tyrosine ligase family protein |
Trichomonas vaginalis | TVAG_176940 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_123200 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_235620 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_008670 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_483220 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_455890 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4640 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4640 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1208000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_230670 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3