Detailed view for LmjF.35.4470

Basic information

TDR Targets ID: 27814
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 3.8659 | Length (AA): 199 | MW (Da): 21522 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04969   CS domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 115 1ejf (A) 1 110 33.00 0 1 1.01 -0.55
2 92 1rl1 (A) 138 225 36.00 0.0000029 1 0.94 -1.1
7 122 2cg9 (X) 18 135 23.00 0 1 0.73 0.34
1 115 1ejf (A) 1 110 36.00 0 1 1.07539 -1.17
7 122 2cg9 (X) 18 135 23.00 0 1 0.827415 -0.13
124 199 1txg (A) 242 306 35.00 0.89 0.13 0.44781 1.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127481)

Species Accession Gene Product
Arabidopsis thaliana AT3G03773   p23 co-chaperone protein
Arabidopsis thaliana AT4G02450   HSP20-like chaperone
Babesia bovis BBOV_III004670   conserved hypothetical protein
Brugia malayi Bm1_30235   Hypothetical 19.4 kDa protein ZC395.10 in chromosome III
Candida albicans CaO19.13172   HSP90 associated co-chaperone
Candida albicans CaO19.5749   HSP90 associated co-chaperone
Caenorhabditis elegans CELE_ZC395.10   Protein ZC395.10
Cryptosporidium hominis Chro.60200   p23 co-chaperone
Cryptosporidium parvum cgd6_1630   p23; HSP20-like chaperones fold
Dictyostelium discoideum DDB_G0268042   hypothetical protein
Drosophila melanogaster Dmel_CG16817   CG16817 gene product from transcript CG16817-RA
Echinococcus granulosus EgrG_001059400   hsp90 co chaperone tebp
Echinococcus multilocularis EmuJ_001059400   hsp90 co chaperone (tebp)
Giardia lamblia GL50803_10429   Wos2 protein
Homo sapiens ENSG00000110958   prostaglandin E synthase 3 (cytosolic)
Leishmania braziliensis LbrM.34.4450   hypothetical protein, conserved
Leishmania braziliensis LbrM.20.0220   hypothetical protein, conserved
Leishmania donovani LdBPK_354540.1   Co-chaperone protein P23
Leishmania donovani LdBPK_340230.1   CS domain containing protein, putative
Leishmania infantum LinJ.35.4540   hypothetical protein, conserved
Leishmania infantum LinJ.34.0230   hypothetical protein, conserved
Leishmania major LmjF.34.0210   hypothetical protein, conserved
Leishmania major LmjF.35.4470   hypothetical protein, conserved
Leishmania mexicana LmxM.33.0210   hypothetical protein, conserved
Leishmania mexicana LmxM.34.4470   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_07411   hypothetical protein
Mus musculus ENSMUSG00000071072   prostaglandin E synthase 3 (cytosolic)
Mus musculus 102641464   prostaglandin E synthase 3-like
Neospora caninum NCLIV_004390   p23, related
Oryza sativa 4333609   Os03g0655300
Oryza sativa 4332979   Os03g0381300
Oryza sativa 4345369   Os08g0359500
Plasmodium berghei PBANKA_1317400   co-chaperone p23, putative
Plasmodium falciparum PF3D7_1453700   co-chaperone p23
Plasmodium knowlesi PKNH_1228400   co-chaperone p23, putative
Plasmodium vivax PVX_117795   hypothetical protein, conserved
Plasmodium yoelii PY00792   34 kDa phosphoprotein
Saccharomyces cerevisiae YKL117W   Sba1p
Schistosoma japonicum Sjp_0212790   Protein wos2, putative
Schistosoma mansoni Smp_072900.1   hsp90 co-chaperone (tebp)
Schistosoma mansoni Smp_072900.2   hsp90 co-chaperone (tebp)
Schmidtea mediterranea mk4.001672.07   Hsp90 co-chaperone
Trypanosoma brucei gambiense Tbg972.9.5930   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.10.3260   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.10230   Co-chaperone protein P23
Trypanosoma brucei Tb927.10.2620   CS domain containing protein, putative
Trypanosoma congolense TcIL3000_10_2240   CS domain containing protein, putative
Trypanosoma cruzi TcCLB.506195.170   CS domain containing protein, putative
Trypanosoma cruzi TcCLB.507007.70   Co-chaperone protein P23
Trypanosoma cruzi TcCLB.506407.60   CS domain containing protein, putative
Trypanosoma cruzi TcCLB.509551.70   Co-chaperone protein P23
Toxoplasma gondii TGME49_321520   hypothetical protein
Theileria parva TP02_0486   hypothetical protein
Trichomonas vaginalis TVAG_007320   butyrate induced transcript, putative
Trichomonas vaginalis TVAG_388410   co-chaperone, putative
Trichomonas vaginalis TVAG_475160   HSP90 co-chaperone, putative

Essentiality

LmjF.35.4470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2620 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2620 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.2620 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.2620 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.1690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1690 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.1690 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.1690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZC395.10 Caenorhabditis elegans embryonic lethal wormbase
TGME49_321520 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.4470 (Leishmania major), hypothetical protein, conserved
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