Detailed view for LmjF.36.5500

Basic information

TDR Targets ID: 27835
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.8575 | Length (AA): 363 | MW (Da): 41132 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03006   Haemolysin-III related

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
65 361 3wxw (A) 100 377 32.00 0 0.46 1.05238 0.2
76 348 3wxv (A) 100 353 38.00 0 0.3 0.938166 0.97
76 263 1xio (A) 32 224 10.00 0.54 0 0.577106 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127242)

Species Accession Gene Product
Arabidopsis thaliana AT5G20270   heptahelical transmembrane protein1
Arabidopsis thaliana AT4G30850   heptahelical transmembrane protein2
Arabidopsis thaliana AT4G37680   heptahelical transmembrane protein HHP4
Arabidopsis thaliana AT2G24150   heptahelical protein 3
Arabidopsis thaliana AT4G38320   heptahelical protein 5
Brugia malayi Bm1_38245   ADIPOR-like receptor C43G2.1
Brugia malayi Bm1_19050   ADIPOR-like receptor C43G2.1
Candida albicans CaO19.7716   Haemolysin III-related protein similar to S. cerevisiae YDR492W and PHO36 (YOL002C) integral membrane protein involved in phospa
Candida albicans CaO19.55   Haemolysin III-related protein similar to S. cerevisiae YDR492W and PHO36 (YOL002C) integral membrane protein involved in phospa
Caenorhabditis elegans CELE_Y32H12A.5   Protein PAQR-2
Caenorhabditis elegans CELE_C43G2.1   Protein PAQR-1
Dictyostelium discoideum DDB_G0293072   hypothetical protein
Drosophila melanogaster Dmel_CG5315   Adiponectin receptor
Echinococcus granulosus EgrG_001023750   Hly III
Echinococcus granulosus EgrG_000869800   adiponectin receptor
Echinococcus multilocularis EmuJ_000869800   adiponectin receptor
Echinococcus multilocularis EmuJ_001023700   Hly III
Homo sapiens ENSG00000006831   adiponectin receptor 2
Homo sapiens ENSG00000159346   adiponectin receptor 1
Leishmania braziliensis LbrM.35.5750   hypothetical protein, conserved
Leishmania braziliensis LbrM.35.5790   hypothetical protein, conserved
Leishmania braziliensis LbrM.35.5780   hypothetical protein, conserved
Leishmania donovani LdBPK_365760.1   Haemolysin-III related, putative
Leishmania donovani LdBPK_365750.1   Haemolysin-III related, putative
Leishmania donovani LdBPK_365740.1   Haemolysin-III related, putative
Leishmania infantum LinJ.36.5750   hypothetical protein, conserved
Leishmania infantum LinJ.36.5760   hypothetical protein, conserved
Leishmania infantum LinJ.36.5740   hypothetical protein, conserved
Leishmania major LmjF.36.5500   hypothetical protein, conserved
Leishmania major LmjF.36.5510   hypothetical protein, conserved
Leishmania major LmjF.36.5520   hypothetical protein, conserved
Leishmania mexicana LmxM.36.5510   hypothetical protein, conserved
Leishmania mexicana LmxM.36.5520   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_06306   adiponectin receptor 1b
Loa Loa (eye worm) LOAG_03847   adipor-like receptor
Mus musculus 72674   adiponectin receptor 1
Mus musculus ensembl-mmu:ENSMUSG00000030168   adiponectin receptor 2
Oryza sativa 4352324   Os12g0511200
Oryza sativa 4332161   Os03g0232900
Oryza sativa 4328501   Os02g0179500
Oryza sativa 4341641   Os06g0643700
Oryza sativa 4341697   Os06g0652200
Saccharomyces cerevisiae YDR492W   Izh1p
Saccharomyces cerevisiae YOL002C   Izh2p
Schistosoma japonicum Sjp_0018340   ko:K07297 adiponectin receptor, putative
Schistosoma japonicum Sjp_0124820   ADIPOR-like receptor CG5315, putative
Schistosoma japonicum Sjp_0200390   ADIPOR-like receptor CG5315, putative
Schistosoma japonicum Sjp_0302860   ADIPOR-like receptor CG5315, putative
Schistosoma mansoni Smp_045410   adiponectin receptor
Schistosoma mansoni Smp_045420   adiponectin receptor
Schistosoma mansoni Smp_057130   adiponectin receptor
Schmidtea mediterranea mk4.001382.02   Adiponectin receptor protein
Schmidtea mediterranea mk4.010777.00   Adiponectin receptor protein
Schmidtea mediterranea mk4.004363.02  
Schmidtea mediterranea mk4.005338.00   Adiponectin receptor protein
Schmidtea mediterranea mk4.003161.02   Adiponectin receptor protein
Schmidtea mediterranea mk4.010951.00  
Trypanosoma brucei gambiense Tbg972.10.11400   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.10.11390   adiponectin receptor protein 1
Trypanosoma brucei Tb927.10.9300   adiponectin receptor protein 1
Trypanosoma brucei Tb927.10.9310   Haemolysin-III related, putative
Trypanosoma congolense TcIL3000_10_8080   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_8070   adiponectin receptor protein 1
Trypanosoma cruzi TcCLB.504137.140   Haemolysin-III related, putative
Trypanosoma cruzi TcCLB.509799.100   Haemolysin-III related, putative
Trypanosoma cruzi TcCLB.504137.150   Haemolysin-III related, putative
Trypanosoma cruzi TcCLB.509799.90   Haemolysin-III related, putative

Essentiality

LmjF.36.5500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.9300 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.9300 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.9300 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.9300 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.9310 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.9310 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.9310 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.9310 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y32H12A.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adiponectin receptor 1 Compounds References
Homo sapiens adiponectin receptor 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0068 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.5500 (Leishmania major), hypothetical protein, conserved
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