Detailed view for LmjF.22.0460

Basic information

TDR Targets ID: 27979
Leishmania major, 40S ribosomal protein S15, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.804 | Length (AA): 152 | MW (Da): 17435 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00203   Ribosomal protein S19

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
53 137 1fjg (S) 2 85 37.00 0 1 0.96 -0.06
12 137 4kzy (P) 5 130 60.00 0 1 1.43285 0.66
54 134 2vqe (S) 3 82 36.00 0 1 0.932395 0.44
62 145 3a1p (B) 10 92 35.00 0 1 1.01313 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126687)

Species Accession Gene Product
Arabidopsis thaliana AT5G63070   40S ribosomal protein S15-6
Arabidopsis thaliana AT5G09510   40S ribosomal protein S15-4
Arabidopsis thaliana AT5G47320   40S ribosomal protein S19
Arabidopsis thaliana ArthCp063   30S ribosomal protein S19
Arabidopsis thaliana AT1G04270   40S ribosomal protein S15-1
Arabidopsis thaliana AT5G09500   40S ribosomal protein S15-3
Arabidopsis thaliana AT5G43640   40S ribosomal protein S15-5
Arabidopsis thaliana AT5G09490   40S ribosomal protein S15-2
Babesia bovis BBOV_II005090   40S ribosomal protein S15, putative
Brugia malayi Bm1_48210   40S ribosomal protein S15
Candida albicans CaO19.13348   likely cytosolic ribosomal protein similar to S. cerevisiae RPS15 (YOL040C) small subunit protein S15
Candida albicans CaO19.5927   likely cytosolic ribosomal protein similar to S. cerevisiae RPS15 (YOL040C) small subunit protein S15
Caenorhabditis elegans CELE_F36A2.6   Protein RPS-15
Cryptosporidium hominis Chro.60368   ribosomal protein S19
Cryptosporidium parvum cgd6_3180   40S ribosomal protein S15
Chlamydia trachomatis CT_524   30S ribosomal protein S19
Dictyostelium discoideum DDB_G0285561   40S ribosomal protein S15
Dictyostelium discoideum DidioMp25   ribosomal protein S19
Drosophila melanogaster Dmel_CG8332   Ribosomal protein S15
Escherichia coli b3316   30S ribosomal subunit protein S19
Echinococcus granulosus EgrG_000876600   40s ribosomal protein s15
Entamoeba histolytica EHI_046690   40S ribosomal protein S15, putative
Entamoeba histolytica EHI_064570   40S ribosomal protein S15, putative
Entamoeba histolytica EHI_111980   40S ribosomal protein S15, putative
Echinococcus multilocularis EmuJ_000876600   40s ribosomal protein s15
Giardia lamblia GL50803_15260   Ribosomal protein S15
Homo sapiens ENSG00000115268   ribosomal protein S15
Leishmania braziliensis LbrM.22.0400   40S ribosomal protein S15, putative
Leishmania donovani LdBPK_220310.1   40S ribosomal protein S15, putative
Leishmania infantum LinJ.22.0340   40S ribosomal protein S15, putative
Leishmania infantum LinJ.22.0310   40S ribosomal protein S15, putative
Leishmania major LmjF.22.0460   40S ribosomal protein S15, putative
Leishmania major LmjF.22.0420   40S ribosomal protein S15, putative
Leishmania mexicana LmxM.22.0420   40S ribosomal protein S15, putative
Leishmania mexicana LmxM.22.0460   40S ribosomal protein S15, putative
Loa Loa (eye worm) LOAG_01726   40S ribosomal protein S15
Mycobacterium leprae ML1859c   PROBABLE 30S RIBOSOMAL PROTEIN S19 RPSS
Mus musculus 102642592   40S ribosomal protein S15-like
Mus musculus ENSMUSG00000063457   ribosomal protein S15
Mycobacterium tuberculosis Rv0705   30S ribosomal protein S19 RpsS
Mycobacterium ulcerans MUL_0794   30S ribosomal protein S19
Neospora caninum NCLIV_013320   hypothetical protein
Oryza sativa 6450135   ribosomal protein S19
Oryza sativa 3131441   30S ribosomal protein S19
Oryza sativa 4342580   Os07g0184300
Oryza sativa 4334438   Os03g0798600
Plasmodium berghei PBANKA_1416300   40S ribosomal protein S19, putative
Plasmodium falciparum PF3D7_1317800   40S ribosomal protein S19
Plasmodium knowlesi PKNH_1418500   40S ribosomal protein S19, putative
Plasmodium vivax PVX_122710   40S ribosomal protein S19, putative
Plasmodium yoelii PY00188   ribosomal protein S19
Saccharomyces cerevisiae YOL040C   ribosomal 40S subunit protein S15
Saccharomyces cerevisiae YNR037C   mitochondrial 37S ribosomal protein RSM19
Schistosoma japonicum Sjp_0215650   ko:K02958 small subunit ribosomal protein S15e, putative
Schistosoma mansoni Smp_130850   40S ribosomal protein S15
Schmidtea mediterranea mk4.000446.07   40S ribosomal protein S15
Trypanosoma brucei gambiense Tbg972.7.2610   40S ribosomal protein S15, putative
Trypanosoma brucei gambiense Tbg972.7.2640   40S ribosomal protein S15, putative
Trypanosoma brucei Tb927.7.2370   40S ribosomal protein S15, putative
Trypanosoma brucei Tb927.7.2340   40S ribosomal protein S15, putative
Trypanosoma congolense TcIL3000_7_1690   40S ribosomal protein S15, putative
Trypanosoma cruzi TcCLB.511809.99   40S ribosomal protein S15, putative
Trypanosoma cruzi TcCLB.511809.130   40S ribosomal protein S15, putative
Trypanosoma cruzi TcCLB.511811.10   40S ribosomal protein S15, putative
Toxoplasma gondii TGME49_213350   ribosomal protein RPS15
Treponema pallidum TP0193   30S ribosomal protein S19
Theileria parva TP04_0050   40S ribosomal protein S15, putative
Trichomonas vaginalis TVAG_126060   40S ribosomal protein S15, putative
Trichomonas vaginalis TVAG_055940   40S ribosomal protein S15, putative
Trichomonas vaginalis TVAG_074310   40S ribosomal protein S15, putative
Trichomonas vaginalis TVAG_208960   30S ribosomal protein S19, putative
Wolbachia endosymbiont of Brugia malayi Wbm0337   30S ribosomal protein S19

Essentiality

LmjF.22.0460 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu717 Mycobacterium tuberculosis essential nmpdr
Tb927.7.2340 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.2340 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.2340 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.2340 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3316 Escherichia coli essential goodall
CELE_F36A2.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F36A2.6 Caenorhabditis elegans larval arrest wormbase
CELE_F36A2.6 Caenorhabditis elegans larval lethal wormbase
CELE_F36A2.6 Caenorhabditis elegans slow growth wormbase
CELE_F36A2.6 Caenorhabditis elegans sterile wormbase
YOL040C Saccharomyces cerevisiae inviable yeastgenome
TGME49_213350 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LmjF.22.0460 (Leishmania major), 40S ribosomal protein S15, putative
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