Detailed view for PF3D7_1450400

Basic information

TDR Targets ID: 2809
Plasmodium falciparum, zinc finger protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.9188 | Length (AA): 1844 | MW (Da): 220398 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016538   cyclin-dependent protein kinase regulator activity  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  
GO:0007049   cell cycle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
110 194 1jm7 (A) 6 81 32.00 0.023 0.46 0.0779954 0.85
881 1077 4ux7 (A) 51 220 29.00 0.97 0.16 0.090833 1.07
1145 1587 4r6i (A) 8 475 17.00 0.047 0.61 0.319239 0.67
1534 1783 4o87 (A) 22 314 31.00 0.002 0.19 0.0734748 0.6
1621 1731 4ll8 (E) 65 175 23.00 0.86 0.02 0.374095 -1.31
1108 1323 4tql (A) 9 232 15.00 0.78 0.22 0.248311 -0.35
1525 1774 4o87 (A) 22 314 31.00 0.0024 0.25 0.0980398 0.43
1569 1752 2ap3 (A) 9 194 16.00 0.6 0.01 0.341272 -1.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, early ring, late ring, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, early schizont, early trophozoite, late schizont, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_153772)

Species Accession Gene Product
Plasmodium berghei PBANKA_1314100   zinc finger protein, putative
Plasmodium falciparum PF3D7_1450400   zinc finger protein, putative
Plasmodium knowlesi PKNH_1231700   zinc finger protein, putative
Plasmodium vivax PVX_117965   hypothetical protein, conserved
Plasmodium yoelii PY01986   hypothetical protein
Plasmodium yoelii PY04120   ERYTHROCYTE MEMBRANE PROTEIN PFEMP3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1450400 (Plasmodium falciparum), zinc finger protein, putative
Title for this comment
Comment