pI: 6.9559 |
Length (AA): 398 |
MW (Da): 44373 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 397 | 2c7y (A) | 45 | 439 | 21.00 | 0 | 1 | 1.17 | -1.2 |
8 | 395 | 2es8 (A) | 41 | 425 | 35.00 | 0 | 1 | 1.47 | -1.23 |
9 | 396 | 1m3k (A) | 5 | 391 | 28.00 | 0 | 1 | 1.44 | -1.39 |
3 | 396 | 4c2j (A) | 1 | 395 | 22.00 | 0.000000072 | 1 | 1.28245 | -0.31 |
5 | 395 | 2ib8 (A) | 38 | 425 | 32.00 | 0 | 1 | 1.44411 | -0.77 |
6 | 397 | 4n45 (A) | 1 | 392 | 26.00 | 0.0000000054 | 1 | 1.37742 | -0.81 |
9 | 396 | 2vu1 (A) | 5 | 391 | 28.00 | 0 | 1 | 1.35937 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | gametocyte, early schizont, early trophozoite, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late ring, late schizont, Oocyst. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Female Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Ring, Sporozoite, Male Gametocyte. | Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_126757)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G47720 | acetoacetyl-CoA thiolase 1 |
Arabidopsis thaliana | AT5G48230 | acetoacetyl-CoA thiolase 2 |
Babesia bovis | BBOV_I002980 | thiolase, N-terminal and C-terminal domain containing protein |
Brugia malayi | Bm1_21865 | acetyl-CoA acyltransferases family protein |
Candida albicans | CaO19.1591 | similar to Acetoacetyl-CoA Thiolase A |
Caenorhabditis elegans | CELE_T02G5.8 | Protein KAT-1 |
Caenorhabditis elegans | CELE_T02G5.7 | Protein T02G5.7 |
Caenorhabditis elegans | CELE_F53A2.7 | Protein F53A2.7 |
Dictyostelium discoideum | DDB_G0271544 | acetoacetyl-CoA thiolase |
Drosophila melanogaster | Dmel_CG10932 | CG10932 gene product from transcript CG10932-RB |
Drosophila melanogaster | Dmel_CG4600 | yippee interacting protein 2 |
Drosophila melanogaster | Dmel_CG9149 | CG9149 gene product from transcript CG9149-RA |
Escherichia coli | b2224 | acetyl-CoA acetyltransferase |
Escherichia coli | b2844 | short chain acyltransferase |
Echinococcus granulosus | EgrG_000976900 | acetyl coenzyme A acetyltransferase cytosolic |
Echinococcus multilocularis | EmuJ_000976900 | acetyl coenzyme A acetyltransferase, cytosolic |
Echinococcus multilocularis | EmuJ_000976800 | acetyl coenzyme A C acetyltransferase |
Giardia lamblia | GL50803_3287 | Acetyl-CoA acetyltransferase |
Homo sapiens | 39 | acetyl-CoA acetyltransferase 2 |
Homo sapiens | 10449 | acetyl-CoA acyltransferase 2 |
Homo sapiens | ENSG00000075239 | acetyl-CoA acetyltransferase 1 |
Loa Loa (eye worm) | LOAG_05273 | acetyl-CoA acyltransferase |
Mycobacterium leprae | ML1158 | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA4 (ACETOACETYL-CoA THIOLASE) |
Mus musculus | ENSMUSG00000036880 | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) |
Mus musculus | ENSMUSG00000032047 | acetyl-Coenzyme A acetyltransferase 1 |
Mus musculus | ENSMUSG00000062480 | acetyl-Coenzyme A acetyltransferase 3 |
Mus musculus | ENSMUSG00000023832 | acetyl-Coenzyme A acetyltransferase 2 |
Mycobacterium tuberculosis | Rv1323 | Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase) |
Mycobacterium ulcerans | MUL_3938 | acetyl-CoA acetyltransferase |
Mycobacterium ulcerans | MUL_0357 | beta-ketoacyl CoA thiolase |
Neospora caninum | NCLIV_069850 | hypothetical protein |
Oryza sativa | 4346520 | Os09g0252100 |
Oryza sativa | 4326136 | Os01g0110400 |
Plasmodium berghei | PBANKA_1314600 | acetyl-CoA acetyltransferase, putative |
Plasmodium falciparum | PF3D7_1450900 | acetyl-CoA acetyltransferase, putative |
Plasmodium knowlesi | PKNH_1231200 | acetyl-CoA acetyltransferase, putative |
Plasmodium vivax | PVX_117935 | acetyl-CoA acetyltransferase, putative |
Plasmodium yoelii | PY01991 | acetyl-coa acetyltransferase |
Saccharomyces cerevisiae | YPL028W | acetyl-CoA C-acetyltransferase |
Schistosoma japonicum | Sjp_0214830 | Golgin subfamily A member 7, putative |
Schistosoma japonicum | Sjp_0049670 | Nucleosome-remodeling factor subunit NURF301, putative |
Schistosoma japonicum | Sjp_0081390 | ko:K00626 acetyl-CoA C-acetyltransferase [EC2.3.1.9], putative |
Schistosoma mansoni | Smp_129330 | acetyl-CoA C-acetyltransferase |
Schmidtea mediterranea | mk4.002054.00 | Acetyl-CoA C-acetyltransferase |
Schmidtea mediterranea | mk4.002169.05 | HL08109p |
Schmidtea mediterranea | mk4.004278.03 | Acetyl-CoA acetyltransferase, mitochondrial |
Schmidtea mediterranea | mk4.000144.09 | Acetyl-CoA acetyltransferase, mitochondrial |
Schmidtea mediterranea | mk4.006024.01 | Acetyl-CoA acetyltransferase, mitochondrial |
Schmidtea mediterranea | mk4.010354.01 | Acetyl-CoA acetyltransferase, mitochondrial |
Schmidtea mediterranea | mk4.001907.03 | 3-ketoacyl-CoA thiolase, mitochondrial |
Trypanosoma cruzi | TcCLB.511003.60 | acetyl-CoA acetyltransferase, putative |
Toxoplasma gondii | TGME49_301120 | acetyl-CoA acetyltransferase |
Trichomonas vaginalis | TVAG_258280 | acetyl-CoA acetyltransferase 2, putative |
Trichomonas vaginalis | TVAG_083530 | acetyl-CoA C-acyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b2224 | Escherichia coli | non-essential | goodall |
b2844 | Escherichia coli | non-essential | goodall |
CELE_T02G5.7 | Caenorhabditis elegans | slow growth | wormbase |
YPL028W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1314600 | Plasmodium berghei | Essential | plasmo |
TGME49_301120 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6