Detailed view for Smp_156570

Basic information

TDR Targets ID: 282866
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 9.1617 | Length (AA): 203 | MW (Da): 22448 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0042273   ribosomal large subunit biogenesis and assembly  
GO:0005730   nucleolus  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 142 5ltg (A) 85 233 32.00 0.7 0.63 0.821707 0.85
5 203 1r5m (A) 223 425 10.00 0.0000000001 0.05 0.892596 0.52
80 180 5t5d (A) 43 147 27.00 0.31 0.7 0.591737 0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129959)

Species Accession Gene Product
Arabidopsis thaliana AT1G29320   WD40 domain-containing protein
Brugia malayi Bm1_23025   NOP seven associated protein 1
Candida albicans CaO19.9731   similar to S. cerevisiae YGL111W
Candida albicans CaO19.2185   similar to S. cerevisiae YGL111W
Caenorhabditis elegans CELE_T06E6.1   Protein T06E6.1
Dictyostelium discoideum DDB_G0290555   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG7845   CG7845 gene product from transcript CG7845-RB
Echinococcus granulosus EgrG_000881100   WD repeat containing protein 74
Echinococcus multilocularis EmuJ_000881100   WD repeat containing protein 74
Homo sapiens ENSG00000133316   WD repeat domain 74
Leishmania braziliensis LbrM.09.0020   hypothetical protein, conserved
Leishmania donovani LdBPK_090020.1   hypothetical protein, conserved
Leishmania infantum LinJ.09.0020   hypothetical protein, conserved
Leishmania major LmjF.09.0005   hypothetical protein, conserved
Leishmania mexicana LmxM.09.0005   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10388   NOP seven associated protein 1
Mus musculus ENSMUSG00000042729   WD repeat domain 74
Oryza sativa 4343330   Os07g0506700
Onchocerca volvulus OVOC6400  
Saccharomyces cerevisiae YGL111W   Nsa1p
Schistosoma japonicum Sjp_0313270   IPR011047,Quinonprotein alcohol dehydrogenase-like,domain-containing
Schistosoma japonicum Sjp_0049460   WD repeat-containing protein 74, putative
Schistosoma mansoni Smp_156570   hypothetical protein
Schmidtea mediterranea mk4.002739.00  
Schmidtea mediterranea mk4.001212.05  
Trypanosoma brucei gambiense Tbg972.11.13470   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.12030   hypothetical protein, conserved
Trypanosoma congolense TcIL3000.11.12670   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511479.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.504005.60   hypothetical protein, conserved
Trichomonas vaginalis TVAG_394400   conserved hypothetical protein

Essentiality

Smp_156570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T06E6.1 Caenorhabditis elegans larval arrest wormbase
CELE_T06E6.1 Caenorhabditis elegans slow growth wormbase
YGL111W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_156570 (Schistosoma mansoni), hypothetical protein
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