pI: 8.6622 |
Length (AA): 633 |
MW (Da): 68932 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
14 | 251 | 5ltg (A) | 34 | 446 | 42.00 | 0 | 1 | 0.804987 | -0.19 |
166 | 244 | 5nnz (B) | 176 | 250 | 31.00 | 0.06 | 0.86 | 0.488803 | -0.28 |
463 | 551 | 6e29 (A) | 17 | 99 | 14.00 | 0.028 | 0.03 | 0.2795 | -0.92 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128573)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G30510 | autophagy-related protein 18b |
Brugia malayi | Bm1_24185 | hypothetical protein |
Candida albicans | CaO19.6064 | similar to P.pastoris Gsa12 and S. cerevisiae ATG18 (YFR021W) required for cytoplasm-to-vacuole transport, pexophagy, and autoph |
Candida albicans | CaO19.13485 | similar to P.pastoris Gsa12 and S. cerevisiae ATG18 (YFR021W) required for cytoplasm-to-vacuole transport, pexophagy, and autoph |
Caenorhabditis elegans | CELE_F41E6.13 | Protein ATG-18, isoform B |
Dictyostelium discoideum | DDB_G0285375 | WD repeat domain phosphoinositide-interacting family protein |
Drosophila melanogaster | Dmel_CG8678 | Autophagy-specific gene 18b |
Drosophila melanogaster | Dmel_CG7986 | Autophagy-specific gene 18a |
Echinococcus granulosus | EgrG_001139000 | WD40 repeat domain containing protein |
Echinococcus multilocularis | EmuJ_001139000 | WD40 repeat domain containing protein |
Homo sapiens | ENSG00000157954 | WD repeat domain, phosphoinositide interacting 2 |
Homo sapiens | ENSG00000070540 | WD repeat domain, phosphoinositide interacting 1 |
Loa Loa (eye worm) | LOAG_09134 | hypothetical protein |
Loa Loa (eye worm) | LOAG_09135 | hypothetical protein |
Mus musculus | 74781 | WD repeat domain, phosphoinositide interacting 2 |
Mus musculus | ENSMUSG00000041895 | WD repeat domain, phosphoinositide interacting 1 |
Oryza sativa | 4337929 | Os05g0169200 |
Oryza sativa | 4330978 | Os02g0791800 |
Saccharomyces cerevisiae | YFR021W | Atg18p |
Schistosoma japonicum | Sjp_0012950 | WD repeat domain phosphoinositide-interacting protein 2, putative |
Schistosoma mansoni | Smp_150510 | wipi-2 |
Schmidtea mediterranea | mk4.037414.00 | |
Schmidtea mediterranea | mk4.025088.00 | |
Schmidtea mediterranea | mk4.025088.02 | WD repeat domain phosphoinositide-interacting protein 1 |
Trypanosoma brucei gambiense | Tbg972.3.4560 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.4150 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506175.50 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509669.100 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_226490 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_483310 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.4150 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.4150 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.4150 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.4150 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F41E6.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F41E6.13 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F41E6.13 | Caenorhabditis elegans | slow growth | wormbase |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.