Detailed view for Smp_124640

Basic information

TDR Targets ID: 283015
Schistosoma mansoni, dna2/nam7 helicase family member

Source Database / ID:  GeneDB

pI: 6.1457 | Length (AA): 1605 | MW (Da): 184778 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00534   Glycosyl transferases group 1
PF13086   AAA domain
PF13087   AAA domain
PF16399   Intron-binding protein aquarius N-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0000398   nuclear mRNA splicing, via spliceosome  
GO:0005681   spliceosome  
GO:0009058   biosynthetic process  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 1482 4pj3 (A) 19 1381 47.00 0 1 1.40371 -0.3
826 897 5i45 (A) 249 320 38.00 0.24 0.97 0.55046 -0.58
1446 1531 3zjx (A) 61 150 31.00 0.23 0.02 0.100183 1.66
1489 1602 4m02 (A) 555 656 29.00 0.69 0.04 0.085628 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129398)

Species Accession Gene Product
Arabidopsis thaliana AT2G38770   embryo defective 2765
Babesia bovis BBOV_I001910   conserved hypothetical protein
Brugia malayi Bm1_22610   hypothetical protein
Caenorhabditis elegans CELE_Y80D3A.2   Protein EMB-4, isoform C
Dictyostelium discoideum DDB_G0274797   hypothetical protein
Drosophila melanogaster Dmel_CG31368   CG31368 gene product from transcript CG31368-RD
Echinococcus granulosus EgrG_000865100   intron binding protein aquarius
Entamoeba histolytica EHI_200000   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000865100   intron binding protein aquarius
Homo sapiens 9716   aquarius intron-binding spliceosomal factor
Loa Loa (eye worm) LOAG_13789   AQR protein
Loa Loa (eye worm) LOAG_13552   AQR protein
Loa Loa (eye worm) LOAG_10559   hypothetical protein
Loa Loa (eye worm) LOAG_08893   hypothetical protein
Mus musculus ENSMUSG00000040383   aquarius
Neospora caninum NCLIV_057470   hypothetical protein, conserved
Oryza sativa 4332999   Os03g0387000
Plasmodium berghei PBANKA_1365300   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium falciparum PF3D7_1352700   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium knowlesi PKNH_1248300   P-loop containing nucleoside triphosphate hydrolase, putative
Plasmodium vivax PVX_083530   hypothetical protein, conserved
Plasmodium yoelii PY01194   hypothetical protein
Schistosoma japonicum Sjp_0014090   Intron-binding protein aquarius, putative
Schistosoma japonicum Sjp_0109970   Intron-binding protein aquarius, putative
Schistosoma mansoni Smp_124640   dna2/nam7 helicase family member
Schmidtea mediterranea mk4.002452.05   Intron-binding protein aquarius
Toxoplasma gondii TGME49_314410   aquarius, putative
Theileria parva TP03_0144   hypothetical protein, conserved
Trichomonas vaginalis TVAG_038650   splicing endonuclease positive effector sen1, putative

Essentiality

Smp_124640 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y80D3A.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y80D3A.2 Caenorhabditis elegans slow growth wormbase
TGME49_314410 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_124640 (Schistosoma mansoni), dna2/nam7 helicase family member
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