Detailed view for Smp_095470

Basic information

TDR Targets ID: 283239
Schistosoma mansoni, mps one binder kinase activator-like 2 (mob1 homolog 2) (protein mob3)
Source Database / ID:  GeneDB

pI: 7.5247 | Length (AA): 217 | MW (Da): 25704 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03637   Mob1/phocein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 215 5brk (A) 10 211 53.00 0 1 1.69158 -1.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127063)

Species Accession Gene Product
Arabidopsis thaliana AT5G20440   Mob1/phocein family protein
Arabidopsis thaliana AT4G19045   Mob1/phocein family protein
Arabidopsis thaliana AT5G45550   maintenance of ploidy protein MOB1
Brugia malayi Bm1_35195   Mob1/phocein family protein
Brugia malayi Bm1_38385   Mob1/phocein family protein
Candida albicans CaO19.5528   similar to C terminus of S. cerevisiae MOB1
Candida albicans CaO19.12974   similar to C terminus of S. cerevisiae MOB1
Caenorhabditis elegans CELE_T12B3.4   Protein T12B3.4
Cryptosporidium hominis Chro.40379   hypothetical protein
Cryptosporidium hominis Chro.40380   hypothetical protein
Cryptosporidium parvum cgd4_3350   hypothetical protein
Dictyostelium discoideum DDB_G0292758   Mps1 binder-like protein
Dictyostelium discoideum DDB_G0293706   Mps1 binder-like protein
Dictyostelium discoideum DDB_G0278907   Mps1 binder-like protein
Drosophila melanogaster Dmel_CG4946   CG4946 gene product from transcript CG4946-RA
Drosophila melanogaster Dmel_CG13852   mob as tumor suppressor
Echinococcus granulosus EgrG_000189500   mps one binder kinase activator 1
Echinococcus granulosus EgrG_000240600   mps one binder kinase activator 2a
Entamoeba histolytica EHI_159570   Mob1/phocein family protein
Entamoeba histolytica EHI_159630   Mob1/phocein family protein
Entamoeba histolytica EHI_148520   Mob1/phocein family protein
Entamoeba histolytica EHI_065750   Mob1/phocein family protein
Echinococcus multilocularis EmuJ_000189500   mps one binder kinase activator 1
Echinococcus multilocularis EmuJ_000240600   mps one binder kinase activator 2a
Giardia lamblia GL50803_11044   Mob1-like protein
Homo sapiens ENSG00000120162   MOB kinase activator 3B
Homo sapiens ENSG00000172081   MOB kinase activator 3A
Homo sapiens 55233   MOB kinase activator 1A
Homo sapiens ENSG00000173542   MOB kinase activator 1B
Leishmania braziliensis LbrM.06.0940   cell cycle associated protein MOB1, putative
Leishmania donovani LdBPK_060990.1   cell cycle associated protein MOB1, putative
Leishmania infantum LinJ.06.0990   cell cycle associated protein MOB1, putative
Leishmania major LmjF.06.0960   cell cycle associated protein MOB1, putative
Leishmania mexicana LmxM.06.0960   cell cycle associated protein MOB1, putative
Loa Loa (eye worm) LOAG_08108   Mob1/phocein family protein
Loa Loa (eye worm) LOAG_14864   hypothetical protein
Mus musculus ENSMUSG00000006262   MOB kinase activator 1B
Mus musculus ENSMUSG00000073910   MOB kinase activator 3B
Mus musculus ENSMUSG00000003348   MOB kinase activator 3A
Mus musculus ENSMUSG00000043131   MOB kinase activator 1A
Neospora caninum NCLIV_044420   hypothetical protein
Oryza sativa 4333310   Os03g0577200
Oryza sativa 4348552   Os10g0396300
Onchocerca volvulus OVOC4699  
Saccharomyces cerevisiae YIL106W   Mob1p
Schistosoma japonicum Sjp_0204630   ko:K06685 maintenance of ploidy protein MOB1 (MPS1 binder 1), putative
Schistosoma japonicum Sjp_0210400   ko:K06685 maintenance of ploidy protein MOB1 (MPS1 binder 1), putative
Schistosoma mansoni Smp_070610.2   hypothetical protein
Schistosoma mansoni Smp_095470   mps one binder kinase activator-like 2 (mob1 homolog 2) (protein mob3)
Schistosoma mansoni Smp_070610.1   hypothetical protein
Schmidtea mediterranea mk4.002700.02   MOB kinase activator-like 3
Schmidtea mediterranea mk4.018592.00   MOB kinase activator-like 1
Schmidtea mediterranea mk4.003142.02   MOB kinase activator-like 1
Trypanosoma brucei gambiense Tbg972.7.6460   cell cycle associated protein MOB1, putative
Trypanosoma brucei Tb927.7.5580   cell cycle associated protein MOB1-B
Trypanosoma brucei Tb927.7.5570   cell cycle associated protein MOB1-A
Trypanosoma congolense TcIL3000_7_4580   cell cycle associated protein MOB1, putative
Trypanosoma cruzi TcCLB.510303.190   cell cycle associated protein MOB1, putative
Toxoplasma gondii TGME49_304730   Mob1/phocein family protein
Trichomonas vaginalis TVAG_344540   maintenance of ploidy protein mob1, putative
Trichomonas vaginalis TVAG_314030   maintenance of ploidy protein mob2, putative

Essentiality

Smp_095470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.5570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.5570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.5570 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.5570 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
YIL106W Saccharomyces cerevisiae inviable yeastgenome
TGME49_304730 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_095470 (Schistosoma mansoni), mps one binder kinase activator-like 2 (mob1 homolog 2) (protein mob3)
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