Detailed view for Smp_159750

Basic information

TDR Targets ID: 283314
Schistosoma mansoni, vacuolar protein sorting
Source Database / ID:  GeneDB

pI: 7.4273 | Length (AA): 1157 | MW (Da): 132072 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07928   Vps54-like protein
PF10475   Vacuolar-sorting protein 54, of GARP complex

Gene Ontology

Mouse over links to read term descriptions.
GO:0042147   retrograde transport, endosome to Golgi  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 1146 1u6g (C) 5 1192 10.00 0 1 0.959371 0.8
1019 1155 3n1e (A) 838 973 26.00 0 1 0.57161 -1.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129527)

Species Accession Gene Product
Arabidopsis thaliana AT4G19490   protein VPS54
Brugia malayi Bm1_11650   Vps54 protein
Candida albicans CaO19.9558   microtubule assembly
Candida albicans CaO19.2007   microtubule assembly
Caenorhabditis elegans CELE_T21C9.2   Protein VPS-54, isoform B
Dictyostelium discoideum DDB_G0272985   vacuolar protein sorting 54 family protein
Drosophila melanogaster Dmel_CG3766   scattered
Echinococcus granulosus EgrG_000520500   vacuolar protein sorting
Echinococcus multilocularis EmuJ_000520450   hypothetical protein
Homo sapiens ENSG00000143952   vacuolar protein sorting 54 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_09562   hypothetical protein
Loa Loa (eye worm) LOAG_09559   Vps54 protein
Mus musculus ENSMUSG00000020128   vacuolar protein sorting 54 (yeast)
Oryza sativa 9267478   Os04g0212100
Saccharomyces cerevisiae YDR027C   Vps54p
Schistosoma japonicum Sjp_0104410   IPR000886,Endoplasmic reticulum targeting sequence,domain-containing
Schistosoma japonicum Sjp_0002090   Vacuolar protein sorting-associated protein 54, putative
Schistosoma mansoni Smp_159750   vacuolar protein sorting
Schmidtea mediterranea mk4.000051.22  
Schmidtea mediterranea mk4.000051.18   Vacuolar protein sorting-associated protein 54
Schmidtea mediterranea mk4.000051.19   Vacuolar protein sorting-associated protein 54
Schmidtea mediterranea mk4.000051.21  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_159750 (Schistosoma mansoni), vacuolar protein sorting
Title for this comment
Comment