Detailed view for Smp_165930

Basic information

TDR Targets ID: 283391
Schistosoma mansoni, flightless-I
Source Database / ID:  GeneDB

pI: 6.4324 | Length (AA): 1324 | MW (Da): 152456 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00626   Gelsolin repeat
PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0051014   actin filament severing  
GO:0051015   actin filament binding  
GO:0005515   protein binding  
GO:0003779   actin binding  
GO:0030036   actin cytoskeleton organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 418 4u09 (A) 43 404 38.00 0 1 0.653678 -0.14
51 433 5gr8 (A) 116 514 32.00 0 1 0.536775 0.01
53 408 4u08 (A) 62 405 36.00 0 1 0.738382 -0.61
53 384 4u06 (A) 39 356 37.00 0 1 0.751255 -0.82
138 585 3oja (A) 57 462 26.00 0.00011 1 0.432869 0.94
242 305 4u09 (A) 349 414 34.00 0 0.99 0.539338 -1.11
247 415 4tzh (A) 33 198 35.00 0 1 0.684143 -1.28
261 421 5kh1 (A) 64 183 43.00 0.0000017 0.91 0.223101 0.68
521 1321 3ffn (A) 23 744 27.00 0 1 0.768485 0.42
1217 1324 2llf (A) 2 103 39.00 0 0.97 0.421571 0.19
1217 1313 5a1m (A) 250 347 25.00 0 0.94 0.441263 -1.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133648)

Species Accession Gene Product
Brugia malayi Bm1_10750   Leucine Rich Repeat family protein
Caenorhabditis elegans CELE_B0523.5   Protein FLI-1
Drosophila melanogaster Dmel_CG1484   flightless I
Echinococcus granulosus EgrG_000235000   protein flightless 1
Echinococcus multilocularis EmuJ_000235000   protein flightless 1
Homo sapiens ENSG00000177731   flightless I homolog (Drosophila)
Loa Loa (eye worm) LOAG_06698   hypothetical protein
Mus musculus 102642960   protein flightless-1 homolog
Mus musculus ENSMUSG00000002812   flightless I homolog (Drosophila)
Schistosoma japonicum Sjp_0104170   Protein flightless-1, putative
Schistosoma japonicum Sjp_0104160   Protein flightless-1, putative
Schistosoma japonicum Sjp_0087730   Protein flightless-1, putative
Schistosoma mansoni Smp_165930   flightless-I
Schmidtea mediterranea mk4.003969.01   Putative flightless-I
Schmidtea mediterranea mk4.006753.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_165930 (Schistosoma mansoni), flightless-I
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