Detailed view for Smp_165220

Basic information

TDR Targets ID: 283561
Schistosoma mansoni, embryonic ectoderm development protein
Source Database / ID:  GeneDB

pI: 7.1191 | Length (AA): 507 | MW (Da): 55635 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0035098   ESC/E(Z) complex  
GO:0016571   histone methylation  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
75 507 5u5t (A) 79 440 36.00 0.0000000022 1 1.02434 0.27
76 507 5u5t (A) 80 440 48.00 0 1 1.18547 -0.12
189 316 6g6m (A) 6 120 25.00 0.00093 0.66 0.471865 -0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130364)

Species Accession Gene Product
Arabidopsis thaliana AT3G20740   polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
Brugia malayi Bm1_14690   WD domain containing protein
Caenorhabditis elegans CELE_C09G4.5   Protein MES-6
Drosophila melanogaster Dmel_CG5202   CG5202 gene product from transcript CG5202-RA
Drosophila melanogaster Dmel_CG14941   extra sexcombs
Echinococcus granulosus EgrG_000597500   polycomb protein EED
Echinococcus multilocularis EmuJ_000597500   polycomb protein EED
Homo sapiens ENSG00000074266   embryonic ectoderm development
Loa Loa (eye worm) LOAG_06723   WD domain-containing protein
Mus musculus ENSMUSG00000030619   embryonic ectoderm development
Oryza sativa 9271694   Os08g0137250
Oryza sativa 4344620   Os08g0137100
Schistosoma japonicum Sjp_0055160   Polycomb protein esc, putative
Schistosoma japonicum Sjp_0304860   Polycomb protein esc, putative
Schistosoma mansoni Smp_165220   embryonic ectoderm development protein
Schmidtea mediterranea mk4.003314.01   Putative embryonic ectoderm development protein
Schmidtea mediterranea mk4.003314.00   EED-1

Essentiality

Smp_165220 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C09G4.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C09G4.5 Caenorhabditis elegans larval lethal wormbase
CELE_C09G4.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens embryonic ectoderm development Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0115 0.2645 0.2645
0.0298 0.2806 0.2803
0.0096 0.2645 0.2645
0.0115 0.2645 0.2645
0.0281 0.2816 0.2809
0.0214 0.2655 0.2655
0.0092 0.2645 0.2645
0.031 0.2818 0.2816
0.0329 0.2753 0.2753
0.0115 0.2645 0.2645
0.0285 0.282 0.2831
0.0214 0.2655 0.2655
0.0218 0.2642 0.2642
0.0411 0.2663 0.2655
0.033 0.2815 0.2812
0.0115 0.2602 0.2602
0.0412 0.2605 0.2605
0.0196 0.279 0.279

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_165220 (Schistosoma mansoni), embryonic ectoderm development protein
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