Detailed view for Smp_063580.2

Basic information

TDR Targets ID: 283600
Schistosoma mansoni, n-acetyltransferase mak3
Source Database / ID:  GeneDB

pI: 5.4013 | Length (AA): 198 | MW (Da): 23137 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00583   Acetyltransferase (GNAT) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008080   N-acetyltransferase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 189 2ge3 (A) 6 168 18.00 0 1 0.977277 -0.45
39 189 4r3l (A) 11 167 31.00 0 1 1.18013 -0.78
40 191 6c9m (B) 1 153 31.00 0 1 1.20328 -0.61
79 184 1ghe (A) 60 164 20.00 0 0.87 0.788454 0.09
101 166 2c27 (A) 224 299 36.00 0.42 0.59 0.532733 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128097)

Species Accession Gene Product
Arabidopsis thaliana AT2G38130   N-terminal acetyltransferase complex C component MAK3
Brugia malayi Bm1_25890   L-A virus GAG protein N-acetyltransferase
Candida albicans CaO19.12087   potential N-acetyl tranferase (GNAT family) similar to S. cerevisiae MAK3 (YPR051W) peptide alpha-N-acetyltransferase
Candida albicans CaO19.4617   potential N-acetyl tranferase (GNAT family) similar to S. cerevisiae MAK3 (YPR051W) peptide alpha-N-acetyltransferase
Caenorhabditis elegans CELE_B0238.10   Protein B0238.10
Dictyostelium discoideum DDB_G0285803   hypothetical protein
Drosophila melanogaster Dmel_CG32319   CG32319 gene product from transcript CG32319-RA
Drosophila melanogaster Dmel_CG11412   CG11412 gene product from transcript CG11412-RA
Echinococcus granulosus EgrG_000574500   n acetyltransferase mak3
Echinococcus granulosus EgrG_000247600   n acetyltransferase mak3
Echinococcus granulosus EgrG_000575600   n acetyltransferase mak3
Entamoeba histolytica EHI_123240   acetyltransferase, GNAT family
Echinococcus multilocularis EmuJ_000575300   n acetyltransferase mak3
Echinococcus multilocularis EmuJ_000575600   n acetyltransferase mak3
Echinococcus multilocularis EmuJ_000247600   n acetyltransferase mak3
Echinococcus multilocularis EmuJ_000574500   n acetyltransferase mak3
Giardia lamblia GL50803_13787   Hypothetical protein
Homo sapiens 122830   N(alpha)-acetyltransferase 30, NatC catalytic subunit
Leishmania donovani LdBPK_220330.1   Acetyltransferase (GNAT) family, putative
Leishmania infantum LinJ.22.0330   hypothetical protein, conserved
Leishmania major LmjF.22.0450   hypothetical protein, conserved
Leishmania mexicana LmxM.22.0450   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04503   hypothetical protein
Mus musculus ENSMUSG00000036282   N(alpha)-acetyltransferase 30, NatC catalytic subunit
Neospora caninum NCLIV_027430   acetyltransferase domain-containing protein, putative
Oryza sativa 4350619   Os11g0525800
Plasmodium berghei PBANKA_1225200   acetyltransferase, putative
Plasmodium falciparum PF3D7_0805400   acetyltransferase, putative
Plasmodium knowlesi PKNH_0113800   acetyltransferase, putative
Plasmodium vivax PVX_088280   hypothetical protein, conserved
Plasmodium yoelii PY05005   hypothetical protein
Saccharomyces cerevisiae YPR051W   Mak3p
Schistosoma mansoni Smp_063580.3   n-acetyltransferase mak3
Schistosoma mansoni Smp_063580.2   n-acetyltransferase mak3
Schistosoma mansoni Smp_063580.1   n-acetyltransferase mak3
Schmidtea mediterranea mk4.000059.00   N-alpha-acetyltransferase 30
Schmidtea mediterranea mk4.002215.01   Putative n-acetyltransferase mak3
Trypanosoma brucei gambiense Tbg972.7.2630   N-acetyltransferase, putative
Trypanosoma brucei Tb927.7.2360   N-acetyltransferase, putative
Trypanosoma congolense TcIL3000_0_04550   N-acetyltransferase, putative
Trypanosoma congolense TcIL3000_7_1680   N-acetyltransferase, putative
Trypanosoma cruzi TcCLB.511809.120   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511811.30   hypothetical protein, conserved
Toxoplasma gondii TGME49_259070   acetyltransferase, GNAT family protein
Trichomonas vaginalis TVAG_302110   N-acetyltransferase mak3, putative

Essentiality

Smp_063580.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.2360 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.2360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.2360 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.2360 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1225200 Plasmodium berghei Dispensable plasmo
TGME49_259070 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0003 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_063580.2 (Schistosoma mansoni), n-acetyltransferase mak3
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