Detailed view for Smp_194600

Basic information

TDR Targets ID: 283633
Schistosoma mansoni, mitochondrial carrier protein
Source Database / ID:  GeneDB

pI: 9.0785 | Length (AA): 645 | MW (Da): 70838 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein
PF15985   KH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0003723   RNA binding  
GO:0006810   transport  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 318 6gci (A) 12 305 24.00 0 0.97 0.618812 0.31
38 319 4c9q (A) 16 303 26.00 0 0.56 0.551909 0.53
395 645 2nn6 (G) 74 272 38.00 0 1 0.426447 1.39
469 631 2z0s (A) 62 211 25.00 0.0000074 1 0.369013 0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128098)

Species Accession Gene Product
Arabidopsis thaliana AT4G32175   PNAS-3 related protein
Arabidopsis thaliana AT2G25355   PNAS-3 related protein
Babesia bovis BBOV_III004170   conserved hypothetical protein
Brugia malayi Bm1_07375   exosome complex exonuclease RRP40
Candida albicans CaO19.3304   similar to S. cerevisiae RRP40 (YOL142W) exosome component involved mRNA degradation and nuclear RNA processing
Candida albicans CaO19.10814   similar to S. cerevisiae RRP40 (YOL142W) exosome component involved mRNA degradation and nuclear RNA processing
Caenorhabditis elegans CELE_F59C6.4   Protein EXOS-3
Cryptosporidium hominis Chro.30107   hypothetical protein
Cryptosporidium parvum cgd3_780   hypothetical protein
Dictyostelium discoideum DDB_G0276783   hypothetical protein
Drosophila melanogaster Dmel_CG31938   CG31938 gene product from transcript CG31938-RB
Echinococcus granulosus EgrG_000447400   calcium binding mitochondrial carrier protein
Echinococcus granulosus EgrG_000456300   exosome complex component RRP40
Entamoeba histolytica EHI_004770   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000447400   calcium binding mitochondrial carrier protein
Echinococcus multilocularis EmuJ_000456300   exosome complex component RRP40
Giardia lamblia GL50803_17091   Exosome complex exonuclease, putative
Homo sapiens ENSG00000107371   exosome component 3
Leishmania braziliensis LbrM.04.0170   exosome complex exonuclease RRP40, putative
Leishmania donovani LdBPK_040130.1   exosome complex exonuclease RRP40, putative
Leishmania infantum LinJ.04.0130   exosome complex exonuclease RRP40, putative
Leishmania major LmjF.04.0120   exosome complex exonuclease RRP40, putative
Leishmania mexicana LmxM.04.0120   exosome complex exonuclease RRP40, putative
Loa Loa (eye worm) LOAG_10267   exosome complex exonuclease RRP40
Loa Loa (eye worm) LOAG_06830   exosome complex exonuclease RRP40
Mus musculus ENSMUSG00000028322   exosome component 3
Neospora caninum NCLIV_055960   hypothetical protein
Oryza sativa 4327851   Os01g0661400
Oryza sativa 4324917   Os01g0891400
Plasmodium berghei PBANKA_1405500   exosome complex component RRP40, putative
Plasmodium falciparum PF3D7_1307000   exosome complex component RRP40, putative
Plasmodium knowlesi PKNH_1407300   exosome complex component RRP40, putative
Plasmodium vivax PVX_122185   exosome complex component RRP40, putative
Plasmodium yoelii PY05611   Putative nuclease
Saccharomyces cerevisiae YOL142W   Rrp40p
Schistosoma japonicum Sjp_0122800   Calcium-binding mitochondrial carrier protein SCaMC-3, putative
Schistosoma japonicum Sjp_0068550   ko:K03681 exosome complex exonuclease RRP40, putative
Schistosoma japonicum Sjp_0212620   Calcium-binding mitochondrial carrier protein SCaMC-3, putative
Schistosoma japonicum Sjp_0118030   IPR002067,Mitochondrial carrier protein;IPR001993,Mitochondrial substrate carrier,domain-containing
Schistosoma mansoni Smp_194600   mitochondrial carrier protein
Schmidtea mediterranea mk4.000934.04   Exosome complex component RRP40
Trypanosoma brucei gambiense Tbg972.9.3760   exosome complex exonuclease RRP40, putative
Trypanosoma brucei Tb927.9.7070   exosome complex exonuclease RRP40
Trypanosoma cruzi TcCLB.506625.200   ribosomal RNA processing protein 40, putative
Toxoplasma gondii TGME49_312400   exosomal 3'-5' exoribonuclease complex subunit, putative
Theileria parva TP03_0037   hypothetical protein
Trichomonas vaginalis TVAG_380110   conserved hypothetical protein

Essentiality

Smp_194600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.5160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.5160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.5160 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.5160 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F59C6.4 Caenorhabditis elegans larval arrest wormbase
CELE_F59C6.4 Caenorhabditis elegans sterile wormbase
YOL142W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1405500 Plasmodium berghei Essential plasmo
TGME49_312400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_194600 (Schistosoma mansoni), mitochondrial carrier protein
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