Detailed view for Smp_145510

Basic information

TDR Targets ID: 283648
Schistosoma mansoni, shoc2
Source Database / ID:  GeneDB

pI: 6.5906 | Length (AA): 396 | MW (Da): 44643 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 60 1dce (A) 488 548 27.00 0 0.99 0.554715 -0.93
1 387 4r5d (A) 64 430 30.00 0 1 1.26607 -0.18
4 354 4u08 (A) 54 399 40.00 0 1 1.45216 -1.05
206 356 4tzh (A) 38 187 46.00 0 1 1.07611 -1.44
218 304 4u09 (A) 325 409 45.00 0 1 0.856897 -1.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127136)

Species Accession Gene Product
Arabidopsis thaliana AT1G55610   serine/threonine-protein kinase BRI1-like 1
Arabidopsis thaliana AT3G49670   CLAVATA1-related receptor kinase-like protein
Arabidopsis thaliana AT2G33170   putative leucine-rich repeat receptor-like protein kinase
Arabidopsis thaliana AT5G56040   leucine-rich receptor-like protein kinase
Arabidopsis thaliana AT4G26540   putative LRR receptor-like serine/threonine-protein kinase
Arabidopsis thaliana AT1G73066   Leucine-rich repeat family protein
Arabidopsis thaliana AT3G19700   leucine rich repeat kinase HAIKU 2
Arabidopsis thaliana AT5G07280   leucine-rich repeat receptor protein kinase EMS1
Arabidopsis thaliana AT4G28650   putative leucine-rich repeat transmembrane protein kinase
Arabidopsis thaliana AT5G48940   LRR receptor-like serine/threonine-protein kinase RCH1
Arabidopsis thaliana AT4G20140   LRR receptor-like serine/threonine-protein kinase GSO1
Arabidopsis thaliana AT4G20270   leucine-rich receptor-like protein kinase BAM3
Arabidopsis thaliana AT1G73080   leucine-rich repeat receptor-like protein kinase PEPR1
Arabidopsis thaliana AT3G24240   receptor-like protein kinase 2
Arabidopsis thaliana AT5G25930   protein kinase family protein with leucine-rich repeat domain
Arabidopsis thaliana AT2G01950   serine/threonine-protein kinase BRI1-like 2
Arabidopsis thaliana AT1G28440   receptor-like protein kinase HSL1
Arabidopsis thaliana AT4G28490   receptor-like protein kinase 5
Arabidopsis thaliana AT3G13380   receptor-like protein kinase BRI1-like 3
Arabidopsis thaliana AT5G65710   HAESA-like 2
Arabidopsis thaliana AT5G63930   leucine-rich repeat protein kinase-like protein
Arabidopsis thaliana AT1G08590   CLV1-like leucine rich repeat transmembrane receptor-like protein kinase
Arabidopsis thaliana AT5G49660   receptor like kinase
Arabidopsis thaliana AT4G08850   probable LRR receptor-like serine/threonine-protein kinase
Arabidopsis thaliana AT1G17230   leucine-rich receptor-like protein kinase
Arabidopsis thaliana AT1G34110   leucine-rich receptor-like protein kinase
Arabidopsis thaliana AT5G44700   LRR receptor-like serine/threonine-protein kinase GSO2
Arabidopsis thaliana AT5G61480   leucine-rich repeat receptor-like protein kinase TDR
Arabidopsis thaliana AT1G17750   leucine-rich repeat receptor-like protein kinase PEPR2
Arabidopsis thaliana AT1G75820   receptor protein kinase CLAVATA1
Arabidopsis thaliana AT1G35710   putative leucine-rich repeat receptor-like protein kinase
Arabidopsis thaliana AT4G39400   protein brassinosteroid insensitive 1
Arabidopsis thaliana AT1G09970   leucine-rich receptor-like protein kinase
Arabidopsis thaliana AT5G51350   receptor-like kinase MOL1
Arabidopsis thaliana AT1G72180   leucine-rich receptor-like protein kinase
Arabidopsis thaliana AT5G65700   leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1
Oryza sativa 9272003   Os08g0342300
Oryza sativa 4342080   Os06g0717200
Oryza sativa 4335004   Os04g0132500
Oryza sativa 4346740   Os09g0326100
Oryza sativa 4326546   Os01g0742400
Oryza sativa 4349186   Os10g0527900
Oryza sativa 4347982   Os10g0114400
Oryza sativa 4345424   Os08g0376300
Oryza sativa 4341290   Os06g0557100
Oryza sativa 9271199   Os02g0227600
Oryza sativa 4345707   Os08g0446200
Oryza sativa 4341292   Os06g0557400
Oryza sativa 4324355   Os01g0917500
Oryza sativa 4328049   Os02g0111800
Oryza sativa 4342417   Os07g0152200
Oryza sativa 4331599   Os03g0145000
Oryza sativa 4342345   Os07g0134200
Oryza sativa 4332141   Os03g0228800
Oryza sativa 4328792   Os02g0227700
Oryza sativa 4352873   Os12g0632900
Oryza sativa 4348859   Os10g0469000
Oryza sativa 4325091   Os01g0878300
Oryza sativa 9266544   Os05g0595950
Oryza sativa 4345915   Os08g0493800
Oryza sativa 4334273   Os03g0773700
Oryza sativa 4337933   Os05g0169600
Oryza sativa 4346640   Os09g0293500
Oryza sativa 4324691   Os01g0718300
Oryza sativa 4337937   Os05g0170300
Oryza sativa 4329642   Os02g0553000
Oryza sativa 4348855   Os10g0468500
Oryza sativa 4347998   Os10g0119200
Oryza sativa 4350138   Os11g0232100
Oryza sativa 4348862   Os10g0469600
Oryza sativa 4326367   Os01g0239700
Oryza sativa 4352872   Os12g0632800
Oryza sativa 4327633   Os01g0170300
Oryza sativa 4328793   Os02g0228300
Oryza sativa 4341409   Os06g0589800
Oryza sativa 4343304   Os07g0498400
Schistosoma japonicum Sjp_0100890   Leucine-rich repeat protein SHOC-2, putative
Schistosoma japonicum Sjp_0095570   Leucine-rich repeat protein SHOC-2, putative
Schistosoma mansoni Smp_145510   shoc2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_145510 (Schistosoma mansoni), shoc2
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