Detailed view for Smp_153230

Basic information

TDR Targets ID: 283657
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.1319 | Length (AA): 1317 | MW (Da): 146341 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128025)

Species Accession Gene Product
Arabidopsis thaliana AT5G27490   Integral membrane Yip1 family protein
Arabidopsis thaliana AT3G05280   Integral membrane Yip1 family protein
Brugia malayi Bm1_26855   Yip1 domain containing protein
Candida albicans CaO19.12388   similar to C terminus of S. cerevisiae YGL161
Candida albicans CaO19.4922   similar to C terminus of S. cerevisiae YGL161
Caenorhabditis elegans CELE_Y25C1A.7   Protein Y25C1A.7, isoform B
Cryptosporidium hominis Chro.50129   hypothetical protein
Cryptosporidium parvum cgd5_2490   hypothetical protein with 5 transmembrane domains within C terminus
Dictyostelium discoideum DDB_G0281587   Yip1 domain-containing protein
Drosophila melanogaster Dmel_CG4645   CG4645 gene product from transcript CG4645-RA
Echinococcus granulosus EgrG_000627700   Yip1 domain
Entamoeba histolytica EHI_002670   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000627700   Yip1 domain
Giardia lamblia GL50803_12945   Hypothetical protein
Homo sapiens ENSG00000058799   Yip1 domain family, member 1
Homo sapiens ENSG00000130733   Yip1 domain family, member 2
Leishmania braziliensis LbrM.30.0150   hypothetical protein, conserved
Leishmania donovani LdBPK_300140.1   Yip1 domain containing protein, putative
Leishmania infantum LinJ.30.0140   hypothetical protein, conserved
Leishmania major LmjF.30.0140   hypothetical protein, conserved
Leishmania mexicana LmxM.29.0140   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_07587   hypothetical protein
Mus musculus ENSMUSG00000032182   Yip1 domain family, member 2
Mus musculus ENSMUSG00000057375   Yip1 domain family, member 1
Oryza sativa 4327734   Os01g0610500
Onchocerca volvulus OVOC11084  
Saccharomyces cerevisiae YGL161C   Yip5p
Schistosoma japonicum Sjp_0134450   Fibrocystin-L precursor, putative
Schistosoma mansoni Smp_153230   hypothetical protein
Schmidtea mediterranea mk4.009537.00  
Trypanosoma brucei gambiense Tbg972.6.1200   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.1540   Yip1 domain containing protein, putative
Trypanosoma congolense TcIL3000_6_1030   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.505807.140   Yip1 domain containing protein, putative
Trypanosoma cruzi TcCLB.507017.10   Yip1 domain containing protein, putative
Trichomonas vaginalis TVAG_433690   conserved hypothetical protein
Trichomonas vaginalis TVAG_011530   conserved hypothetical protein

Essentiality

Smp_153230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.1540 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.1540 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.1540 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.1540 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_153230 (Schistosoma mansoni), hypothetical protein
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