Detailed view for Smp_125650

Basic information

TDR Targets ID: 283751
Schistosoma mansoni, inositol polyphosphate multikinase
Source Database / ID:  GeneDB

pI: 6.5355 | Length (AA): 404 | MW (Da): 47030 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03770   Inositol polyphosphate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0032958   inositol phosphate biosynthetic process  
GO:0016301   kinase activity  
GO:0008440   inositol trisphosphate 3-kinase activity  

Metabolic Pathways

Inositol phosphate metabolism (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 268 5w2i (A) 65 394 34.00 0 1 0.943429 -0.31
82 138 2aqx (A) 692 747 43.00 0.018 0.13 0.321189 1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130819)

Species Accession Gene Product
Arabidopsis thaliana AT5G07370   inositol polyphosphate multikinase alpha
Arabidopsis thaliana AT5G61760   inositol polyphosphate multikinase beta
Brugia malayi Bm1_39650   CG13688-PA
Brugia malayi Bm1_39655   inositol polyphosphate 6-/3-/5-kinase 2b
Caenorhabditis elegans CELE_ZK795.1   Protein ZK795.1
Dictyostelium discoideum DDB_G0271760   hypothetical protein
Dictyostelium discoideum DDB_G0281737   hypothetical protein
Drosophila melanogaster Dmel_CG13688   CG13688 gene product from transcript CG13688-RA
Echinococcus granulosus EgrG_001153100   inositol polyphosphate multikinase
Entamoeba histolytica EHI_025390   inositol polyphosphate kinase, putative
Echinococcus multilocularis EmuJ_001153100   inositol polyphosphate multikinase
Echinococcus multilocularis EmuJ_001116050   inositol polyphosphate kinase
Homo sapiens ENSG00000151151   inositol polyphosphate multikinase
Loa Loa (eye worm) LOAG_05109   hypothetical protein
Loa Loa (eye worm) LOAG_05108   hypothetical protein
Mus musculus ENSMUSG00000060733   inositol polyphosphate multikinase
Oryza sativa 4329509   Os02g0523800
Onchocerca volvulus OVOC5052   Inositol polyphosphate multikinase homolog
Schistosoma japonicum Sjp_0059550   expressed protein
Schistosoma japonicum Sjp_0212240   ko:K00328 inositol-polyphosphate multikinase [EC2.7.1.151], putative
Schistosoma mansoni Smp_125650   inositol polyphosphate multikinase
Schmidtea mediterranea mk4.000070.01  
Schmidtea mediterranea mk4.015330.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_125650 (Schistosoma mansoni), inositol polyphosphate multikinase
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