Detailed view for Smp_032180

Basic information

TDR Targets ID: 284018
Schistosoma mansoni, ADP-ribosylation factor arf
Source Database / ID:  GeneDB

pI: 6.4734 | Length (AA): 181 | MW (Da): 20575 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00025   ADP-ribosylation factor family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 181 3lrp (A) 1 181 71.00 0.00000000039 1 2.0131 -2.29
2 180 1r8q (A) 2 180 79.00 0.000000000014 1 2.04105 -1.88
7 180 2b6h (A) 7 180 77.00 0.000000018 1 2.02243 -2.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126696)

Species Accession Gene Product
Arabidopsis thaliana AT1G10630   ADP-ribosylation factor A1F
Arabidopsis thaliana AT1G70490   ARF GTPase family protein
Arabidopsis thaliana AT2G47170   ADP-ribosylation factor 1
Arabidopsis thaliana AT1G23490   ADP-ribosylation factor 1
Arabidopsis thaliana AT3G62290   ADP-ribosylation factor A1E
Arabidopsis thaliana AT5G14670   ADP-ribosylation factor A1B
Babesia bovis BBOV_III004220   ADP-ribosylation factor family protein
Brugia malayi Bm1_01775   ADP-ribosylation factor 1
Brugia malayi Bm1_57025   ADP-ribosylation factor 1
Brugia malayi Bm1_38795   ADP-ribosylation factor 4
Candida albicans CaO19.13805   one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra
Candida albicans CaO19.6447   one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra
Candida albicans CaO19.5964   one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra
Candida albicans CaO19.13385   one of two genes similar to S. cerevisiae ADP-ribosylation factors ARF2 (YDL137W) and ARF1 (YDL192W) involved in ER to Golgi tra
Caenorhabditis elegans CELE_F57H12.1   Protein ARF-3
Caenorhabditis elegans CELE_B0336.2   Protein ARF-1.2
Cryptosporidium hominis Chro.20360   hypothetical protein
Cryptosporidium hominis Chro.30115   ADP ribosylation factor 1
Cryptosporidium parvum cgd3_860   ARF1/2 like small GTpase
Cryptosporidium parvum cgd2_3410   ARF1/2 like small GTpase, putative
Dictyostelium discoideum DDB_G0280479   ADP-ribosylation factor-related
Dictyostelium discoideum DDB_G0289435   ADP-ribosylation factor-related
Dictyostelium discoideum DDB_G0288015   ADP-ribosylation factor-related
Dictyostelium discoideum DDB_G0280633   ADP-ribosylation factor-related
Dictyostelium discoideum DDB_G0280621   ADP-ribosylation factor-related
Dictyostelium discoideum DDB_G0289173   ADP-ribosylation factor
Drosophila melanogaster Dmel_CG8385   ADP ribosylation factor at 79F
Drosophila melanogaster Dmel_CG11027   ADP ribosylation factor at 102F
Echinococcus granulosus EgrG_001177600   ADP ribosylation factor 4
Echinococcus granulosus EgrG_000326000   Arf1 5:ArfA family small GTPase
Entamoeba histolytica EHI_137720   ADP-ribosylation factor 1, putative
Entamoeba histolytica EHI_073470   ADP-ribosylation factor 1, putative
Echinococcus multilocularis EmuJ_001177600   ADP ribosylation factor 4
Echinococcus multilocularis EmuJ_000326000   Arf1 5:ArfA family small GTPase
Echinococcus multilocularis EmuJ_000254750  
Echinococcus multilocularis EmuJ_000674900   ADP ribosylation factor, arf
Giardia lamblia GL50803_7789   ADP-ribosylation factor
Homo sapiens ENSG00000143761   ADP-ribosylation factor 1
Homo sapiens ENSG00000134287   ADP-ribosylation factor 3
Homo sapiens ENSG00000168374   ADP-ribosylation factor 4
Homo sapiens ENSG00000004059   ADP-ribosylation factor 5
Leishmania braziliensis LbrM.31.3150   ADP-ribosylation factor, putative
Leishmania donovani LdBPK_312890.1   ADP-ribosylation factor, putative
Leishmania infantum LinJ.31.2890   ADP-ribosylation factor, putative
Leishmania major LmjF.31.2790   ADP-ribosylation factor, putative
Leishmania mexicana LmxM.30.2790   ADP-ribosylation factor, putative
Loa Loa (eye worm) LOAG_06291   ADP-ribosylation factor 1
Loa Loa (eye worm) LOAG_02200   Arf5 protein
Mus musculus ENSMUSG00000051853   ADP-ribosylation factor 3
Mus musculus ENSMUSG00000020440   ADP-ribosylation factor 5
Mus musculus ENSMUSG00000021877   ADP-ribosylation factor 4
Mus musculus ENSMUSG00000062421   ADP-ribosylation factor 2
Mus musculus ENSMUSG00000048076   ADP-ribosylation factor 1
Neospora caninum NCLIV_007000   ADP-ribosylation factor 4, related
Oryza sativa 4334545   Os03g0811900
Oryza sativa 4326208   Os01g0265100
Oryza sativa 4342746   Os07g0223400
Oryza sativa 4339157   Os05g0489600
Oryza sativa 4342745   Os07g0223100
Oryza sativa 4327591   Os01g0813400
Plasmodium berghei PBANKA_0505100   ADP-ribosylation factor, putative
Plasmodium falciparum PF3D7_1020900   ADP-ribosylation factor
Plasmodium knowlesi PKNH_0605200   ADP-ribosylation factor, putative
Plasmodium vivax PVX_001905   ADP-ribosylation factor, putative
Plasmodium yoelii PY04572   ADP-ribosylation factor
Saccharomyces cerevisiae YDL137W   Arf family GTPase ARF2
Saccharomyces cerevisiae YDL192W   Arf family GTPase ARF1
Schistosoma japonicum Sjp_0133700   ko:K07977 Arf/Sar family, other, putative
Schistosoma japonicum Sjp_0027490   ko:K07937 ADP-ribosylation factor 1, putative
Schistosoma japonicum Sjp_0008190   ko:K07939 ADP-ribosylation factor 4, putative
Schistosoma mansoni Smp_032180   ADP-ribosylation factor arf
Schistosoma mansoni Smp_088650   ADP-ribosylation factor arf
Schmidtea mediterranea mk4.011209.00   ADP-ribosylation factor 1-like 1
Schmidtea mediterranea mk4.030408.01   ADP-ribosylation factor 1-like 2
Schmidtea mediterranea mk4.003484.00   ADP-ribosylation factor 1-like 2
Schmidtea mediterranea mk4.003168.00   ADP-ribosylation factor related
Schmidtea mediterranea mk4.036520.00   ADP-ribosylation factor 1-like 2
Schmidtea mediterranea mk4.000572.03   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.000572.02   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.000572.08   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.002212.02   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.002212.03   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.002212.00   ADP-ribosylation factor-like protein 14
Schmidtea mediterranea mk4.005672.00   ADP ribosylation factor-like 4
Trypanosoma brucei gambiense Tbg972.9.8590   ADP-ribosylation factor, putative
Trypanosoma brucei gambiense Tbg972.9.8610   ADP-ribosylation factor, putative
Trypanosoma brucei Tb927.9.13650   ADP-ribosylation factor, putative
Trypanosoma brucei Tb927.9.13740   ADP-ribosylation factor, putative
Trypanosoma brucei Tb927.9.13710   ADP-ribosylation factor, putative
Trypanosoma brucei Tb927.9.13655   ADP-ribosylation factor, putative
Trypanosoma congolense TcIL3000_9_5880   ADP-ribosylation factor, putative
Trypanosoma congolense TcIL3000_9_5890   ADP-ribosylation factor, putative
Trypanosoma cruzi TcCLB.508415.40   ADP-ribosylation factor 1, putative
Trypanosoma cruzi TcCLB.510755.60   ADP-ribosylation factor 1, putative
Trypanosoma cruzi TcCLB.508415.50   ADP-ribosylation factor 1, putative
Trypanosoma cruzi TcCLB.510755.50   ADP-ribosylation factor 1, putative
Toxoplasma gondii TGME49_276140   ADP ribosylation factor ARF1
Theileria parva TP02_0245   ADP-ribosylation factor, putative
Trichomonas vaginalis TVAG_204680   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_132550   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_255170   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_145360   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_294070   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_148040   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_301220   ADP-ribosylation factor, arf, putative
Trichomonas vaginalis TVAG_064150   ADP-ribosylation factor, arf, putative

Essentiality

Smp_032180 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0336.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0336.2 Caenorhabditis elegans slow growth wormbase
CELE_B0336.2 Caenorhabditis elegans sterile wormbase
CELE_F57H12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F57H12.1 Caenorhabditis elegans larval arrest wormbase
CELE_F57H12.1 Caenorhabditis elegans larval lethal wormbase
CELE_F57H12.1 Caenorhabditis elegans slow growth wormbase
CELE_F57H12.1 Caenorhabditis elegans sterile wormbase
PBANKA_0505100 Plasmodium berghei Essential plasmo
TGME49_276140 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ADP-ribosylation factor 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_032180 (Schistosoma mansoni), ADP-ribosylation factor arf
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