Detailed view for Smp_160260

Basic information

TDR Targets ID: 284111
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 4.3707 | Length (AA): 127 | MW (Da): 14600 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07019   Rab5-interacting protein (Rab5ip)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 75 4dve (A) 106 160 35.00 0.93 0.02 0.453693 2.15
37 88 3ukm (A) 165 209 41.00 0.95 0.44 0.231449 2.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130486)

Species Accession Gene Product
Arabidopsis thaliana AT2G29020   Rab5-interacting-like protein
Arabidopsis thaliana AT5G59410   Rab5-interacting family protein
Brugia malayi Bm1_21665   rab5-interacting protein
Caenorhabditis elegans CELE_F44E7.9   Protein F44E7.9
Cryptosporidium parvum cgd1_1770   putative Rab5-interacting protein
Dictyostelium discoideum DDB_G0289011   hypothetical protein
Drosophila melanogaster Dmel_CG12107   CG12107 gene product from transcript CG12107-RA
Echinococcus granulosus EgrG_000075100   Rab5 interacting
Echinococcus granulosus EgrG_000075200   peptidyl prolyl cis trans isomerase FKBP5
Entamoeba histolytica EHI_196950   hypothetical protein
Echinococcus multilocularis EmuJ_000075100   Rab5 interacting
Homo sapiens ENSG00000101084   chromosome 20 open reading frame 24
Homo sapiens ENSG00000259399   TGIF2-C20orf24 readthrough
Loa Loa (eye worm) LOAG_11502   rab5-interacting protein
Mus musculus ENSMUSG00000027637   RIKEN cDNA 1110008F13 gene
Neospora caninum NCLIV_005490   hypothetical protein, conserved
Oryza sativa 4337590   Os05g0110600
Onchocerca volvulus OVOC5865  
Plasmodium berghei PBANKA_0716300   Rab5-interacting protein, putative
Plasmodium falciparum PF3D7_0414300   Rab5-interacting protein, putative
Plasmodium knowlesi PKNH_0505900   Rab5-interacting protein, putative
Plasmodium vivax PVX_089670   Rab5-interacting protein, putative
Schistosoma japonicum Sjp_0205750   IPR013105,Tetratricopeptide TPR_2,domain-containing
Schistosoma japonicum Sjp_0307510   similar to Uncharacterized protein C20orf24, putative
Schistosoma mansoni Smp_160270   hypothetical protein
Schistosoma mansoni Smp_160260   hypothetical protein
Schmidtea mediterranea mk4.000056.23  
Toxoplasma gondii TGME49_222090   hypothetical protein
Trichomonas vaginalis TVAG_402250   hypothetical protein

Essentiality

Smp_160260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0716300 Plasmodium berghei Dispensable plasmo
TGME49_222090 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_160260 (Schistosoma mansoni), hypothetical protein
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